5 Alpha-Reductase Inhibitory Potential of Solanum Nigrum for Alopecia Management

    January 2024
    Arindam Chakraborty, Arka Bhattacharjee, Manodeep Chakraborty, Goutam Mukhopadhyay
    Image of study
    TLDR Solanum nigrum may help treat hair loss.
    The study explored the potential of Solanum nigrum L., a plant used in Indian medicine, as a 5 alpha-reductase inhibitor for treating androgenic diseases like male pattern hair loss. The plant's inhibitory activity was compared to finasteride, a known 5 alpha-reductase inhibitor. The petroleum ether extract of Solanum nigrum L. and its chemical biomarker, linoleic acid, showed promising results, suggesting potential for future anti-androgenic activity research. The petroleum ether extract was found to be more effective than the methanolic extract as a 5-alpha-reductase inhibitor, with an IC50 value of 125.528±0.634 (μg/ml) compared to 220.724±6.086 (μg/ml) for the methanolic extract. The study supports the use of Solanum nigrum L. for treating hair loss, but more in vivo research is needed to confirm these findings.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 3 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community 19M started minoxidil 5% and dermarolling 4 months ago. First pic is the end of my first month (january 21) and the second is today (april 21). I apply minoxidil 2 times a day and dermaroll 0.5mm once a week. Thoughts?

      in Progress Pictures  71 upvotes 8 months ago
      A 19-year-old male has been using minoxidil 5% and dermarolling for four months to treat hair loss, applying minoxidil twice daily and dermarolling once a week. Commenters suggest consistent treatment, improving picture quality, and adding a 5-alpha-reductase inhibitor to enhance results.

      community Microneedling only with rosemary

      in Microneedling 6 months ago
      A user asked if microneedling, massages, and essential oils can prevent further hair loss in the crown area without using drugs. The response indicated that without a 5-alpha-reductase inhibitor, hair loss will likely continue.

      community 2 month progress with Minoxidil and Dermaroller

      in Minoxidil  412 upvotes 10 months ago
      The conversation discusses a user's two-month hair regrowth progress using Minoxidil and a 0.5mm dermaroller. Some suggest adding a 5-alpha-reductase inhibitor like finasteride or dutasteride to maintain the results.

      community Blood DHT Levels – before and after creatine

      in Research/Science  41 upvotes 1 year ago
      The impact of creatine on DHT levels, and whether it could cause accelerated male pattern baldness (MPB). The user taking a 5 alpha reductase inhibitor found that their DHT levels actually reduced despite taking creatine for nine weeks. Replies suggested looking into testosterone levels as well and debating the safety of creatine use in relation to MPB.

    Similar Research

    5 / 1000+ results