Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts

    March 2021 in “ Frontiers in Cell and Developmental Biology ”
    Mahmood Yaseen Hachim, Noha Mousaad Elemam, Rakhee K. Ramakrishnan, Khuloud Bajbouj, Ronald Olivenstein, Ibrahim Y. Hachim, Saba Al Heialy, Qutayba Hamid, Hauke Busch, Rifat Hamoudi
    TLDR Wnt signaling is disrupted in asthma, affecting cell growth and inflammation.
    The study investigated the role of Wnt signaling in asthma, focusing on bronchial epithelium and fibroblasts. It found that severe asthmatic patients exhibited an imbalance between Wnt enhancers and inhibitors, with Th2-high phenotypes showing increased Wnt-negative regulators and inflammatory asthmatics showing enriched canonical Wnt signaling. These alterations, linked to early lung development, could predispose individuals to asthma and severe phenotypes. Wnt signaling was crucial for cell proliferation and senescence responses, with its inhibition reducing these markers in bronchial fibroblasts. However, in asthmatic fibroblasts, Wnt signaling inhibition was ineffective due to its derangement and other dysfunctional pathways.
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