Prefrontal 5α-Reductase 2 Mediates Male-Specific Acute Stress Response

January 2025 in “ Science Advances ”

Roberto Cadeddu, Giulia Braccagni, Gabriele Floris, Caterina Branca, Eleonora Corridori, Sara Salviati, Pilar Sánchez, Luca Spiro Santovito, Jesús M. Torres, Esperanza Ortega, Graziano Pinna, Philip J. Moos, Simona Scheggi, Marco Bortolato

5α-reductase 5α-reductase 2 5α-reductase 1 allopregnanolone medial prefrontal cortex neurons glia

Studysummary In this study, researchers observed that acute stress increased levels of the enzyme 5αR2 in the medial prefrontal cortex of male rats, affecting stress reactivity, but this effect was not seen in females.

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