Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that the total testosterone/dihydrotestosterone ratio correlates with a negative metabolic profile in both women with PCOS and healthy women.

In this study, testosterone was reported to increase aquaporin levels and water reabsorption in the kidneys of male rats, potentially leading to higher blood pressure, with effects mitigated by flutamide and finasteride.

This study found that applying 2.5% testosterone gel increased facial terminal hairs in young males with beta-thalassemia major and was well tolerated.

This case report describes a 60-year-old postmenopausal woman with virilization and hirsutism caused by hilus-cell hyperplasia, which was confirmed following bilateral salpingo-oophorectomy.

This study found that canine dermal papilla cells and fibroblasts metabolize androgens differently than human hair follicle cells, indicating species-specific differences in androgen metabolism.

Testosterone, DHT, and estradiol significantly affect hair cell growth.

In this study, prolonged intravenous Fenoterol infusion was associated with intensive hair growth in most patients, although hormonal changes typically linked to such effects were not observed.

This study concluded that both vaginal TEST and Estring may be effective for treating vaginal dryness in breast cancer patients on aromatase inhibitors, with adverse events being rare and manageable.

This review discusses phenotypic differences in testosterone production between mice and humans with HSD17B3 deficiency and reports no new findings; the authors highlight potential pathways and enzymes involved in testosterone synthesis.

In this study, long-term normalization of testosterone levels in postmenopausal women with hyperandrogenism did not improve body mass index, glucose, or lipid metabolism.

This study reported that derivatization with 5-butylpicolinic acid improved the sensitivity for detecting testosterone and DHT in saliva using LC-ESI-MS/MS, with minimal interference from the saliva matrix.

This study reported that the n-butanol fraction of Perilla frutescens extract, particularly rosmarinic acid, showed potential for hair regrowth and anti-androgenic activity in male mice, suggesting it as a possible treatment for androgenetic alopecia.

This study found that KH053, combining Panax ginseng and bee-pollen, significantly reduced prostate weight and DHT levels, inhibiting BPH development in a rat model.

This study suggests that in rat skin, testosterone itself may play a more significant role in androgen action than 5α-dihydrotestosterone, unlike in the prostate where 5α-DHT is more dominant.

This review discusses the impact of testosterone therapy on postmenopausal women's sexual function and well-being but notes a lack of long-term safety studies and debates on defining androgen insufficiency.

This review highlights the connection between sex hormones and metabolic dysfunction, emphasizing how conditions like male hypogonadism and female hyperandrogenism can increase the risk and severity of hepatic steatosis, which often progresses alongside metabolic syndrome and elevates mortality risks.

This study found that sex hormones, specifically non-aromatizable androgens like DHT and A/T, significantly increase inflammatory cytokine expression in human adipocytes when stimulated by LPS.

This case series observed that ovarian hyperthecosis can manifest with hyperandrogenism and insulin resistance in postmenopausal women, even when serum testosterone levels are below diagnostic thresholds, suggesting potential gaps in current diagnostic criteria.

This case report describes a testosterone- and cortisol-secreting adrenocortical oncocytoma causing hirsutism in a 23-year-old woman, highlighting adrenal oncocytomas as an important consideration for differential diagnosis.

This study found that an oral testosterone formulation normalized serum testosterone levels and significantly reduced SHBG in men with experimentally induced hypogonadism after nine days of treatment, suggesting potential efficacy for testosterone deficiency.

This review examines existing research on transdermal testosterone for treating hypoactive sexual desire disorder, suggesting it improves female sexual function with minimal side effects but highlights the need for more long-term safety data.

This study demonstrated that testosterone treatment increases muscle strength and alters body composition in transmen, and the addition of dutasteride does not impair these anabolic effects.

This study found that triglycerides, testosterone, and SHBG levels were associated with hyperandrogenism in women with PCOS, while FGS was not linked to this condition.

This study found that testosterone significantly influenced the expression and function of certain ion transporters in the vas deferens, impacting fluid secretion and contributing to a suitable environment for male fertility.

This study found that the risk of urinary stone disease increased significantly in patients with severe androgenetic alopecia, and that testosterone deficiency was more frequent among these patients.

This study found that honokiol inhibits enzymes related to testosterone degradation in vitro, suggesting its potential as a lead compound for developing antiaging bioactive ingredients for men.

This study found that serum testosterone levels significantly increased during major head and neck surgeries in maxillofacial surgeons, influenced by factors like tumor size and procedural complexity.

In a clinical trial, this study found that a modified slow-release oral testosterone formulation improved pharmacokinetics, delaying serum testosterone peaks and reducing serum DHT compared to immediate-release formulations, especially when combined with finasteride.

This study found that women with acne and oligomenorrhea have higher levels of biologically active testosterone compared to those with acne and normal menstrual cycles.

This study found that spironolactone reduced androgenic hormones in hirsute women but had only marginal effects on hair growth, making it no more advisable than other therapies.