A Phase II Study of Vaginal Testosterone Cream Versus Estring for Vaginal Dryness or Decreased Libido in Women with Early Stage Breast Cancer Treated with Aromatase Inhibitors

    December 2009 in “ Cancer Research ”
    M.E. Melisko, Hope S. Rugo, Amy DeLuca, John J. Park, Mark M. Moasser, Pamela N. Münster, Mindy Goldman
    TLDR Both vaginal testosterone cream and Estring effectively manage vaginal dryness in women with early-stage breast cancer on aromatase inhibitors.
    This Phase II study evaluated the safety and efficacy of vaginal testosterone cream (TEST) versus Estring for treating vaginal dryness and decreased libido in women with early-stage breast cancer on aromatase inhibitors. The study planned to enroll 70 patients, with 29 enrolled and 20 completing the 12-week period. Both treatments showed improvement in vaginal atrophy scores, and adverse events were rare. Some patients experienced elevated serum estradiol levels, but these generally returned to baseline. The study concluded that both TEST and Estring were effective options for managing vaginal dryness in this patient population, without reaching the threshold for stopping due to sustained estradiol elevation.
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       23 upvotes 6 years ago
      The user shared their personal experience with hair loss, hormone imbalances, and treatments including testosterone boosters, natural estrogen blockers, and DHEA. They suggest that low-dose finasteride and natural hormone therapy could reduce hair loss with fewer side effects.

      community how about progesterone cream?

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      Progesterone cream might help with hair loss by inhibiting DHT production and suppressing prolactin, which can increase DHT. Some dermatologists have used progesterone for hair loss treatment, and it has been effective, sometimes combined with minoxidil, finasteride, and hydrocortisone.

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