Metabolic Syndrome, Hepatic Steatosis, and Testosterone: A Matter of Sex

    October 2024 in “ Livers ”
    Elena Gangitano, Frank A. Scannapieco, Carla Lubrano, Lucio Gnessi
    Studysummary This review highlights the connection between sex hormones and metabolic dysfunction, emphasizing how conditions like male hypogonadism and female hyperandrogenism can increase the risk and severity of hepatic steatosis, which often progresses alongside metabolic syndrome and elevates mortality risks.
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    Research cited in this study 4

    1. Hyperandrogenism and Cardiometabolic Risk in Pre- and Postmenopausal Women: What Is the Evidence? ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2023
    2. Persistent Poor Metabolic Profile in Postmenopausal Women With Ovarian Hyperandrogenism After Testosterone Level Normalization Journal of the Endocrine Society · 2019
    3. Polycystic Ovary Syndrome, Androgen Excess, and the Risk of Nonalcoholic Fatty Liver Disease in Women: A Longitudinal Study Based on a United Kingdom Primary Care Database PLOS Medicine · 2018
    4. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS) Human Reproduction · 2003