New Insights Into Testosterone Biosynthesis: Novel Observations From HSD17B3 Deficient Mice
December 2022
in “
International journal of molecular sciences
”
Studysummary This review discusses phenotypic differences in testosterone production between mice and humans with HSD17B3 deficiency and reports no new findings; the authors highlight potential pathways and enzymes involved in testosterone synthesis.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study on HSD17B3 deficient mice reveals that despite the deficiency, these mice maintain testosterone production, masculinization, and fertility, unlike humans with HSD17B3 mutations who experience disorders of sexual development due to low testosterone levels. The findings suggest alternative pathways and enzymes, such as HSD17B1, HSD17B5, and HSD17B12, may compensate for the loss of HSD17B3 in mice, highlighting species differences in androgen production. This research underscores the complexity of testosterone biosynthesis and suggests potential targets for novel therapies to regulate testosterone in individuals with deficiencies.
