5 citations
,
May 2018 in “Therapeutic advances in drug safety” This review discusses the role of androgen therapy and neurosteroids in cerebrovascular health, highlighting the potential risks and benefits and the importance of pharmacogenetic testing, but reports no new experimental results.
1 citations
,
April 2022 in “Emergency Medicine Australasia” This article discusses the negative experiences transgender individuals often encounter in emergency healthcare settings and emphasizes the importance of gender-affirming practices, but it reports no new clinical results.
June 2023 in “Clinical and Experimental Dermatology” This systematic review reported that gender-affirming hormone therapy may lead to changes in hair growth patterns, with differing effects for transgender men and women, potentially impacting quality of life.
146 citations
,
January 2004 in “Hormones” This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.
59 citations
,
August 2004 in “Human Reproduction Update” This article discusses the challenges in diagnosing female androgen insufficiency syndrome due to unreliable testosterone measurement methods but notes symptom improvement with testosterone therapy, emphasizing the need for women-specific formulations and safety guidelines.
16 citations
,
April 2025 in “Foods” This study highlights the diverse applications of *Perilla frutescens* in traditional medicine, cuisine, and industrial settings, noting its significant antioxidant and antimicrobial properties in experimental models, as well as research efforts to enhance its bioactive content and ensure safety and standardization.
16 citations
,
June 2022 in “Journal of Pediatric Endocrinology and Metabolism” This study found an association between higher phthalate exposure and increased incidence of precocious puberty in girls, suggesting a need to reduce children's exposure to these endocrine disruptors.
7 citations
,
September 2022 in “Communications biology” This research found that Leydig cells significantly rely on synthesizing omega-6 HUFAs to support male steroid hormone production, highlighting a new role for these fatty acids in the male reproductive system.
3 citations
,
November 2021 in “IntechOpen eBooks” This chapter reviews the role of the testes in producing and functioning of testicular androgens and protein hormones, but it presents no new clinical results.
1 citations
,
July 2023 in “Frontiers in Immunology” This review highlights the role of chronic stress, oxidative stress, and immune processes in the development of Hashimoto’s thyroiditis and polycystic ovary syndrome, emphasizing the potential of antioxidants in their treatment based on the existing literature.
1 citations
,
July 2023 in “F&S Reviews” This review highlights that various commonly prescribed medications for chronic conditions may impact male fertility by affecting hormone secretion, sperm production, ejaculation, erectile function, and libido, although conclusive evidence is limited to specific drug groups.
January 2024 in “Medicina” This review examines the pathogenesis of androgen excess and dyslipidemia in PCOS and the potential role of statins as a treatment but provides no new clinical results.
35 citations
,
October 2011 in “Medicine and science in sports and exercise” This review discusses the role of skeletal muscle in synthesizing bioactive androgens, highlighting that intramuscular androgens may influence muscle via intracrine action, but their precise function remains unclear.
5 citations
,
January 2023 in “Indian Journal of Endocrinology and Metabolism” This consensus document discusses guidelines for gender-affirming hormone therapy in India, offering recommendations based on a review of existing evidence and expert input, without reporting new clinical results.
31 citations
,
December 2023 in “Middle East Fertility Society Journal” This review discusses the relationship between polycystic ovary syndrome and inflammation, highlighting various inflammatory markers, but reports no new clinical results.
10 citations
,
March 2024 in “Endocrine Reviews” In this retrospective review, the author discusses key discoveries in understanding androgen excess disorders like PCOS, focusing on genetic and molecular insights gained from 1965 to 2015.
8 citations
,
December 2022 in “Nature Reviews Endocrinology” This review discusses the roles of sex hormones in COVID-19 progression and highlights conflicting evidence on their protective effects and the complexity of sex and gender influences on the disease.
2 citations
,
February 2025 in “Journal of Nanobiotechnology” In this study, metal-organic frameworks modified with stearic acid were used to deliver cardamonin to hair follicles, significantly promoting hair growth and cell proliferation in testosterone-challenged mice, suggesting potential benefits for androgenic alopecia treatment.
2 citations
,
January 2023 in “Uro” This study found that both a proprietary ultrahigh-pressure extract and a hexanic extract of saw palmetto showed comparable inhibition of 5α-reductase, suggesting similar potential for managing symptoms of benign prostatic hyperplasia.
2 citations
,
August 2022 in “Middle East Fertility Society Journal” This study found that combining fructose and DHT in rats successfully mimicked the clinical phenotypes of non-lean PCOS, providing a novel rodent model for this condition.
2 citations
,
June 2022 in “대한스포츠의학회지” This article reviews the development of selective androgen receptor modulators and myostatin inhibitors as performance-enhancing drugs, highlighting ongoing challenges in achieving truly tissue-selective anabolic agents and reporting no new experimental findings.
1 citations
,
November 2023 in “Endocrine Connections” This study developed a validated gas chromatography–tandem mass spectrometry assay to assess sex steroid hormones in cerebrospinal fluid, finding substantial levels of DHEA, androstenedione, and testosterone, with strong correlations to serum levels, providing insight into sex steroid dynamics in the human CNS.
1 citations
,
August 2022 in “Biomedicines” This review assesses the potential of dutasteride as a promising treatment for ALS due to its reported neuroprotective, antioxidant, and anti-inflammatory effects, but emphasizes that clinical studies are needed for confirmation.
1 citations
,
January 2020 in “Bioscience Reports” This study found that prolonged use of finasteride in women led to altered levels of sex steroids, DNA damage, and increased menstrual bleeding, suggesting adverse health effects without clear benefits for androgenetic alopecia treatment.
March 2026 in “Nutrients” This study found that adequate vitamin D status is necessary for metformin to effectively reduce prolactin levels in men with iatrogenic hyperprolactinemia, while improvements in glycemic control were observed across all vitamin D groups.
November 2025 in “Pharmacological Research” In this study, researchers found that exosome-like nanoparticles isolated from Polygoni Multiflori Radix can promote hair growth in mice by modulating androgen signaling and gene expression, outperforming Minoxidil in testosterone-induced conditions.
June 2025 in “Journal of Drug Delivery Science and Technology” A dissolving microneedle patch with dutasteride offers effective, long-lasting hair loss treatment with fewer side effects.
February 2024 in “Biomedicines” This review examines the hormonal causes of hair loss, noting how androgen excess can lead to follicle miniaturization and linking estrogen deficiency and thyroid dysfunction to common alopecia types. It further discusses hormonal treatments such as finasteride, dutasteride, and spironolactone.
August 2023 in “Journal of Clinical Medicine” This study found that metformin's effect on reducing prolactin levels is less pronounced in women with PCOS compared to control subjects, likely due to higher endogenous testosterone levels, despite improvements in insulin sensitivity in both groups after six months of treatment.
August 2023 in “Medicina-lithuania” This review discusses the degenerative effects of anabolic-androgenic steroids on the nervous system and reports no new experimental results, aiming to increase public awareness of their health risks.