Sex Steroid Levels in Cerebrospinal Fluid and Serum Samples Quantified by Mass Spectrometry in Men

November 2023 in “ Endocrine Connections ”

Henrik Ryberg, Anna‐Karin Norlén, Andreas Landin, Per Johansson, Zeinab Salman, Anders Wallin, Johan Svensson, Claes Ohlsson

dehydroepiandrosterone androstenedione testosterone dihydrotestosterone estradiol estrone progesterone sex steroid hormones cerebrospinal fluid serum gas chromatography–tandem mass spectrometry DHEA DHT E2 E1 GC-MS/MS

This study validated a highly sensitive gas chromatography–tandem mass spectrometry (GC-MS/MS) assay to quantify sex steroid hormones in cerebrospinal fluid (CSF) and serum samples from 47 men. The results showed that dehydroepiandrosterone (DHEA) was the predominant sex steroid in CSF, followed by androstenedione and testosterone, while dihydrotestosterone (DHT), estradiol (E2), and estrone (E1) were present at lower levels, and progesterone was generally undetectable. Strong correlations were found between CSF and serum levels for all sex steroids except E2. The study suggests that testosterone in CSF originates from circulating testosterone, DHT results from local conversion of testosterone, and E2 is derived from local conversion of androstenedione in the CNS. This assay provides a new tool for exploring the role of sex steroids in the human central nervous system.

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community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Cardio for more than 60 minutes reduces DHT levels and improve hair growth

in Research/Science 126 upvotes 8 months ago

Long aerobic exercise (over 60 minutes) can reduce DHT levels and improve hair health. Some users discuss using Tadalafil (Cialis) to further reduce DHT after exercise, while others mention using treatments like Minoxidil, Finasteride, and RU58841 for hair growth.

community 16 months finasteride progress but slowly losing hair again

in Progress Pictures 138 upvotes 9 months ago

A 21-year-old male experienced initial success with finasteride for 16 months but is now losing hair again. He is considering switching to dutasteride and adding oral minoxidil, while also investigating environmental and health factors.

community Please take a vitamin & hormone test

in Chat 259 upvotes 11 months ago

Checking vitamin and hormone levels is important for addressing hair loss, as deficiencies in vitamin D, zinc, and iron can affect hair growth. Treatments like finasteride, minoxidil, and vitamin supplements are used, but addressing deficiencies is crucial for effectiveness.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 2 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

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