Sex Steroid Levels in Cerebrospinal Fluid and Serum Samples Quantified by Mass Spectrometry in Men

    November 2023 in “ Endocrine Connections ”
    Henrik Ryberg, Anna‐Karin Norlén, Andreas Landin … Claes Ohlsson
    Studysummary This study developed a validated gas chromatography–tandem mass spectrometry assay to assess sex steroid hormones in cerebrospinal fluid, finding substantial levels of DHEA, androstenedione, and testosterone, with strong correlations to serum levels, providing insight into sex steroid dynamics in the human CNS.
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    Research cited in this study 3

    1. Weak Correlations Between Serum and Cerebrospinal Fluid Levels of Estradiol, Progesterone, and Testosterone in Males BMC Neuroscience · 2019
    2. Relationships Between Cerebrospinal Fluid GABAergic Neurosteroid Levels and Symptom Severity in Men with PTSD Psychoneuroendocrinology · 2018
    3. Visualizing Androgen Receptor Activity in Male and Female Mice PloS one · 2013