What Does the Research Say About Androgen Use and Cerebrovascular Events?

    May 2018 in “ Therapeutic advances in drug safety ”
    M. Reza Sadaie, Mehdi Farhoudi, Masumeh Zamanlu, Naser Aghamohammadzadeh, Atieh Amouzegar, Robert E. Rosenbaum, Garrett Thomas
    TLDR Androgen use may increase the risk of stroke, but more research is needed.
    The document reviewed the complex relationship between androgen use, particularly testosterone and its metabolites, and cerebrovascular events. It found mixed results, with some studies indicating neuroprotective benefits of testosterone, especially in aging men with low levels, while others suggested increased stroke risk, particularly with high doses or in men with cardiovascular risks. The review emphasized the role of genetic variability in androgen metabolism and the need for genetic testing to predict individual responses. It called for more extensive, high-powered prospective studies to better understand the safety and efficacy of androgen therapy, considering genetic predispositions and the need for individualized treatment strategies. Overall, the long-term effects of androgen therapy on cerebrovascular health remained unclear.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

      community KX-826 Pyrilutamide1% coming soon

      in Update  152 upvotes 1 year ago
      KX-826 Pyrilutamide 1% is launching soon, and users are discussing its potential benefits and drawbacks compared to other treatments like Minoxidil and finasteride. Some users are skeptical about its effectiveness, while others are hopeful it will be a safer alternative.

      community Update: Chest discomfort from RU58841

      in Update  34 upvotes 2 years ago
      A user experienced severe chest pains and shortness of breath after using RU58841 for hair loss and was advised by a doctor that blocking androgens can weaken the heart. They decided to continue with finasteride, minoxidil, and a hair transplant instead.

      community How is dht not beneficial to you?

      in Finasteride/Dutasteride  107 upvotes 3 days ago
      DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

      community Why do people here trust Kevin Mann?

      in Chat  34 upvotes 5 years ago
      Concerns about finasteride's side effects on neurosteroids and brain health, with skepticism towards Kevin Mann's advice. Users discuss using finasteride, minoxidil, and RU58841 for hair loss, with mixed opinions on their safety and effectiveness.

    Similar Research

    5 / 1000+ results