What Does the Research Say About Androgen Use and Cerebrovascular Events?

    May 2018 in “ Therapeutic advances in drug safety ”
    M. Reza Sadaie, Mehdi Farhoudi, Masumeh Zamanlu, Naser Aghamohammadzadeh, Atieh Amouzegar, Robert E. Rosenbaum, Garrett Thomas
    TLDR Androgen use may increase the risk of stroke, but more research is needed.
    The document reviewed the complex relationship between androgen use, particularly testosterone and its metabolites, and cerebrovascular events. It found mixed results, with some studies indicating neuroprotective benefits of testosterone, especially in aging men with low levels, while others suggested increased stroke risk, particularly with high doses or in men with cardiovascular risks. The review emphasized the role of genetic variability in androgen metabolism and the need for genetic testing to predict individual responses. It called for more extensive, high-powered prospective studies to better understand the safety and efficacy of androgen therapy, considering genetic predispositions and the need for individualized treatment strategies. Overall, the long-term effects of androgen therapy on cerebrovascular health remained unclear.
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