Testosterone, Dihydrotestosterone, and Incident Cardiovascular Disease and Mortality in the Cardiovascular Health Study

    June 2014 in “ ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism ”
    Molly M. Shores, Mary L. Biggs, Alice M. Arnold, Nicholas L. Smith, W. T. Longstreth, Jorge R. Kizer, Calvin H. Hirsch, Anne Rentoumis Cappola, Alvin M. Matsumoto
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    TLDR DHT may increase the risk of heart disease and death in elderly men.
    In a longitudinal cohort study of 1032 elderly men (mean age 76), researchers investigated the associations of testosterone (T), calculated free testosterone (cFT), dihydrotestosterone (DHT), and calculated free DHT with incident cardiovascular disease (CVD) and all-cause mortality over a median follow-up of 9 years. The study found that while total T and cFT were not linked to incident CVD or mortality, DHT and calculated free DHT showed curvilinear associations with both incident CVD and all-cause mortality. These findings suggested that DHT and calculated free DHT might be risk factors for CVD and mortality, warranting further research to confirm these results and understand the underlying mechanisms.
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