TLDR Lower testosterone levels may increase heart failure risk in older men.
In a study of 1,061 older men from the Cardiovascular Health Study, researchers found that lower levels of calculated free testosterone were significantly associated with a higher risk of incident heart failure (HF) over a median follow-up of 9.6 years, with a hazard ratio of 1.14. Other hormones, such as total testosterone and dihydrotestosterone, did not show significant associations with HF risk. The findings suggested that testosterone deficiency might contribute to HF incidence, particularly heart failure with reduced ejection fraction (HFrEF), and highlighted the potential of testosterone replacement therapy as a strategy to reduce HF risk. However, further research was needed to confirm these findings, and the study's limitations included a moderate sample size and lack of fasting state specimen collection.
19 citations
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April 2018 in “Clinical cardiology” Older men with low levels of a testosterone byproduct had a higher chance of developing an irregular heartbeat.
56 citations
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January 2015 in “Circulation” Finasteride helps reduce heart issues and improves heart function.
104 citations
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March 2014 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” DHT may increase the risk of heart disease and death in elderly men.
50 citations
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February 2013 in “Annals of Clinical Biochemistry” Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
506 citations
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March 2005 in “The Journal of Clinical Endocrinology and Metabolism” Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.
19 citations
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April 2014 in “Hormones” Hormones and genetics play key roles in male and female baldness, which can affect mental health and may be linked to other health issues.
6 citations
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September 2005 in “Expert Opinion on Pharmacotherapy” Androgen therapy can help with symptoms like low libido in women, but more research is needed to understand its long-term safety and effects on health.
50 citations
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February 2013 in “Annals of Clinical Biochemistry” Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
9 citations
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January 2017 in “Ginekologia Polska” A higher testosterone to dihydrotestosterone ratio may indicate worse metabolic health in women.
3 citations
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July 1993 in “Contraception” Women with moderate body hair have higher levels of certain hormones and may benefit from treatment that increases sex hormone-binding protein.
13 citations
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June 1989 in “Pediatric clinics of North America/The Pediatric clinics of North America” The conclusion is that young women with excessive hair growth should be quickly tested for hormonal issues and treated to improve their social well-being.
