Innovative Reports on the Effects of Anabolic Androgenic Steroid Abuse - How to Lose Your Mind for the Love of Sport

The document discusses the harmful effects of chronic use of Anabolic-androgenic steroids (AAS), testosterone-derived compounds, on various body systems including cardiovascular, musculoskeletal, reproductive, digestive, and nervous systems. AAS misuse can lead to cardiovascular issues like increased vascular resistance, blood pressure, and pro-inflammatory biomarkers, potentially causing conditions like cardiomyopathies, hypertension, and myocardial infarction. In the musculoskeletal system, overuse can lead to muscle damage and rhabdomyolysis. In the reproductive system, AAS can disrupt active spermatogenesis in men, leading to a decrease in the secretion of certain hormones and a reduction in testosterone production. AAS abuse can also cause hormonal changes, gynecomastia, fatigue, depression, and changes in the reproductive system in both men and women, including testicular shrinkage in men and hormonal disorders in women. It can also cause hepatotoxicity, skin changes such as acne and androgenic alopecia, and effects on the nervous system. AAS abuse can lead to the aggregation of beta-amyloid and tau protein, associated with an increased risk of Alzheimer’s and other neurodegenerative diseases, and impair cognitive functions. The document emphasizes the need for public awareness and legal restrictions to prevent AAS misuse.