Novel Uses for the Anabolic Androgenic Steroids Nandrolone and Oxandrolone in the Management of Male Health

The 2016 document reviews the potential therapeutic applications of the anabolic androgenic steroids nandrolone and oxandrolone in treating male health issues, particularly hypogonadism, muscle wasting, and other catabolic disorders. It highlights their favorable myotrophic/androgenic ratios and suggests they could improve muscle mass and strength, as well as potentially increase native testosterone levels when used with exercise in hypogonadal males. The document also introduces selective androgen receptor modulators (SARMs) like enobosarm for muscle wasting in cancer and discusses the use of aromatase inhibitors to increase testosterone production, albeit with caution due to potential bone density reduction. Despite the stigma associated with AAS due to doping, the document suggests that their careful use could offer clinically meaningful benefits for men's health. It compiles evidence from studies spanning from 1962 to 2013, but does not provide specific numbers of participants in these studies.