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    Did you mean T helper 1 cells?
    Glossary T helper 1 cells

    specialized immune cells that produce cytokines to fight infections

    T helper 1 cells, often abbreviated as Th1 cells, are a subset of T cells that play a crucial role in the immune system by producing cytokines like interferon-gamma (IFN-γ). These cytokines help activate macrophages and are essential for defending against intracellular pathogens such as viruses and certain bacteria. Th1 cells are also involved in the pathogenesis of autoimmune diseases by promoting inflammation.

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    1. T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities 2018 · 66 citations
    2. Imbalance of T‐helper 17 and regulatory T cells in patients with alopecia areata The Journal of Dermatology · 2015 · 62 citations
    3. 42905 Role of regulatory T and T-helper 17 cells in patients with acute diffuse and total alopecia Journal of the American Academy of Dermatology · 2023
    4. MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata 2023
    5. The Role of T‐Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis The Journal of Dermatology · 2025 · 1 citations
    6. Detection of subtypes of T helper cells and their cytokines in peripheral blood of patients with systematic lupus erythematosus and their clinical significances Journal of Jilin University · 2014
    7. The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target Clinical & Developmental Immunology · 2012 · 32 citations
    8. The potential of regulatory T cell-based therapies for alopecia areata Frontiers in Immunology · 2023
    9. Role of regulatory T cells in psoriasis pathogenesis and treatment British Journal of Dermatology · 2020 · 273 citations
    10. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    11. CD4 T cells from mice with alopecia areata express an effector like phenotype and can transfer disease The Journal of Immunology · 2023 · 1 citations
    12. T Cells Promote Distinct Transcriptional Programs of Cutaneous Inflammatory Disease in Keratinocytes and Dermal Fibroblasts Journal of Investigative Dermatology · 2025 · 2 citations
    13. P130 The densities of T cells, Langerhans cells, and natural killer cells in uninvolved skin of patients with acne vulgaris Journal of the European Academy of Dermatology and Venereology · 1997
    14. 290 Brepocitinib improves cicatricial alopecia and downregulates key T-helper biomarkers Journal of Investigative Dermatology · 2024
    15. Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation Proceedings of the National Academy of Sciences · 2024 · 16 citations
    16. The role of natural killer cells in autoimmune blistering diseases Autoimmunity · 2011 · 24 citations
    17. Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2024
    18. 176 Myeloid cell-specific deletion of mTOR suppresses psoriasis-like skin inflammation in C57BL/6 mice Journal of Investigative Dermatology · 2023
    19. Decision letter: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    20. PD-1+CXCR5−CD4+T cells are correlated with the severity of systemic lupus erythematosus Rheumatology · 2019 · 71 citations
    21. A humanized IL-2 fusion protein enhances T regulatory cells in vivo and restrains disease in a murine model of Alopecia Areata 4760 The Journal of Immunology · 2025
    22. Postmenopausal frontal fibrosing alopecia. Scarring alopecia in a pattern distribution Archives of Dermatology · 1994 · 332 citations
    23. Postmenopausal Frontal Fibrosing Alopecia Archives of Dermatology · 1994 · 325 citations
    24. Targeting lymphoid-derived IL-17 signaling to delay skin aging Nature Aging · 2023 · 59 citations
    25. Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency ˜The œAmerican journal of pathology · 2015 · 23 citations
    26. Androgenetic alopecia and hair growth promotion state of the art: Present and future Clinics in Dermatology · 1988 · 8 citations
    27. Lupus comédonien Annales de Dermatologie et de Vénéréologie · 2007 · 7 citations
    28. Alopecia Areata: A Complex Cytokine Driven Disease 2020 · 3 citations
    29. Alopecia areata and risk of atopic and autoimmune conditions: population-based cohort study Clinical and Experimental Dermatology · 2022 · 34 citations
    30. An ROS‐Scavenging Treg‐Recruiting Hydrogel Patch for Diabetic Wound Healing Advanced Functional Materials · 2024