PD-1+ CXCR5− CD4+ T Cells Are Correlated with the Severity of Systemic Lupus Erythematosus

    May 2019 in “ Rheumatology ”
    Jin Lin, Ye Yu, Jilin Ma, Chunyun Ren, Weiqian Chen
    TLDR Tph cells are linked to the severity of systemic lupus erythematosus.
    The study demonstrated that PD-1+CXCR5−CD4+T peripheral helper (Tph) cells were significantly increased in patients with systemic lupus erythematosus (SLE) compared to healthy controls and were associated with disease activity and severity. Higher levels of Tph cells correlated with clinical parameters such as ESR, IgG, complement levels (C3 and C4), IL-21 levels, and ANA titre, and were elevated in patients with specific symptoms like arthritis, nephritis, rash, and alopecia. These findings suggested that Tph cells played a crucial role in SLE pathogenesis and could serve as biomarkers for predicting disease flare, highlighting the potential of targeting IL-21 and the Tph–B cell axis for SLE treatment.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Should I get transplant #4 or just shave my head?

      in Transplants  171 upvotes 8 months ago
      A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

      community Are Derma Rollers Actually Harmful in the Long Run?

      in Microneedling  40 upvotes 1 month ago
      Derma rollers may cause scarring alopecia, leading some to prefer dermastamps or dermapens for microneedling. Combining minoxidil with microneedling is effective, but proper technique and healing time are essential to prevent damage.

      community Only Minoxidil 2 Months Before After Photos

      in Progress Pictures  132 upvotes 1 year ago
      A user shared their 2-month hair growth progress using only Minoxidil, noting significant improvement and plans to continue despite a genetic predisposition to baldness. They apply Minoxidil twice daily, experienced a heat rash, and chose not to use Finasteride due to side effects.

      community Rare Non responder to Finasteride, Dutasteride, and oral minoxidil

      in Minoxidil  78 upvotes 1 year ago
      A user did not respond to finasteride, dutasteride, and oral minoxidil for hair loss after four years of treatment and is considering scalp micropigmentation (SMP). Other users suggest the hair loss pattern may indicate alopecia areata and recommend seeing a dermatologist.

      community GT20029. Kintor Pharma’s Product

      in Research/Science  13 upvotes 2 years ago
      The conversation discusses GT20029, a compound by Kintor Pharma that degrades androgen receptors and is in trials, with potential as a hair loss cure. Another promising treatment mentioned is an antibody that blocks prolactin and has shown positive results in macaques.

      community Hair greed made me switch to Dut too early

      in Chat  42 upvotes 1 month ago
      The user switched from finasteride to dutasteride for hair loss but faced increased shedding and anxiety, regretting not staying with finasteride longer. Other users shared mixed experiences, advising patience with dutasteride, as it may take up to a year to show results.

    Similar Research

    5 / 1000+ results