Androgenetic Alopecia And Hair Growth Promotion: Present And Future

October 1988 in “ Clinics in Dermatology ”

Vera H. Price

androgenetic alopecia hair growth promotion androgens genetics Minoxidil Diazoxide Viprostol Cyclosporine A DNA synthesis keratinocyte reproduction T-helper cells cyclic AMP hair follicle control Rogaine

TLDR Current research explores hair growth drugs, while future research aims for personalized treatments.

This article discusses current and future research on androgenetic alopecia and hair growth promotion. Current research focuses on drugs that promote hair growth, while future research aims to identify new targets for hair growth promotion and personalized treatments for patients. The article explains the role of androgens and genetics in baldness and outlines the four phases of research on hair growth promotion. The focus is on finding active hair growth-promoting sites on drug molecules. The document discusses potential drugs for promoting hair growth, including Minoxidil, Diazoxide, Viprostol, and Cyclosporine A. These drugs have been found to enhance DNA synthesis and keratinocyte reproduction or selectively inhibit T-helper cells, making them potential candidates for future hair growth treatments. The article also explores the potential role of cyclic AMP in hair follicle control and growth.

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Research cited in this study

14 / 14 results

research The Metabolism and Control Mechanism of Human Hair Follicles

22 citations, April 2015 in “Current problems in dermatology”

Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.

research Action of Topical Minoxidil in the Bald Stump-Tailed Macaque

78 citations, March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil promotes hair growth but stops working when discontinued.

research Topical Minoxidil (3%) in Extensive Alopecia Areata, Including Long-Term Efficacy

54 citations, March 1987 in “Journal of The American Academy of Dermatology”

3% topical minoxidil effectively treats extensive alopecia areata with few side effects.

research Topical Tretinoin for Hair Growth Promotion

73 citations, October 1986 in “Journal of the American Academy of Dermatology”

Tretinoin may help hair growth and works better when combined with minoxidil.

research Topical Minoxidil in Early Male Pattern Baldness

138 citations, August 1985 in “Journal of The American Academy of Dermatology”

Minoxidil promotes hair growth in male pattern baldness.

research Topical Minoxidil Therapy in Hereditary Androgenetic Alopecia

55 citations, February 1985 in “Archives of Dermatology”

Using minoxidil on the scalp can help grow hair for people with hereditary baldness.

research Alopecia Areata Treated With Topical Minoxidil

78 citations, April 1984 in “Archives of Dermatology”

Minoxidil can help regrow hair in alopecia areata patients.

research Direct Effects of Minoxidil on Epidermal Cells in Culture

63 citations, January 1984 in “Journal of Investigative Dermatology”

Minoxidil promotes hair growth by increasing cell division and DNA synthesis.

research Effect of Minoxidil on Cultured Keratinocytes

72 citations, December 1983 in “Journal of Investigative Dermatology”

Minoxidil helps hair cells live longer and grow longer.

research Treatment of Hirsutism With Spironolactone

183 citations, March 1982 in “JAMA”

Spironolactone is a safe and effective treatment for reducing excessive hair growth in women.

research Effect of Cyproterone Acetate on Hair Growth, Sebaceous Secretion, and Endocrine Parameters in a Hirsute Subject

66 citations, October 1977 in “British journal of dermatology/British journal of dermatology, Supplement”

Cyproterone acetate reduces hair growth and oil production.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations, September 1977 in “British Journal of Dermatology”

Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.

research Testosterone Metabolism in the Skin

74 citations, November 1975 in “Archives of dermatology”

Increased DHT formation in skin can cause hair loss, acne, and excessive hair growth, and antiandrogens might treat these conditions.

research Use of Cyproterone Acetate in the Treatment of Acne, Hirsutism, and Virilism

232 citations, June 1975 in “Journal of Steroid Biochemistry”

Cyproterone acetate is effective for acne but less so for hirsutism and alopecia, with some side effects and quick menstrual cycle recovery after treatment.

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