In this review, the authors highlight that drugs promoting androgenic activity or inhibiting estrogenic activity may unmask or worsen androgenetic alopecia in genetically predisposed individuals, indicating the need for careful management in clinical settings.
February 2024 in “Biomedicines” This review examines the hormonal causes of hair loss, noting how androgen excess can lead to follicle miniaturization and linking estrogen deficiency and thyroid dysfunction to common alopecia types. It further discusses hormonal treatments such as finasteride, dutasteride, and spironolactone.
January 2024 in “Cosmetics” In this study, Brazilian postmenopausal women reported that menopause significantly deteriorates the quality of their skin, nails, and hair, negatively affecting self-esteem and quality of life, with a need for better understanding of hormone replacement therapy's dermatological effects.
April 2023 in “Mayo Clinic Proceedings” Estrogen may help improve COVID-19 outcomes, especially in women.
July 2012 in “International Journal of Trichology” This article discusses various aspects of hair and scalp health, ancient philosophical perspectives on hair, and causes of hair disorders in children, without reporting new clinical results.
502 citations
,
February 2008 in “The Journal of Clinical Endocrinology & Metabolism” This review discusses hirsutism management guidelines, recommending androgen testing only for women with abnormal hirsutism scores and advocating for combined therapy approaches depending on severity and underlying conditions, but it reports no new clinical results.
29 citations
,
October 2020 in “Environmental health perspectives” This study found that several preservatives, including triclocarban and triclosan, showed potential endocrine-disrupting effects on various nuclear receptors in both in silico and in vitro models.
21 citations
,
January 2015 in “Dental research journal” In this study, women with polycystic ovary syndrome were found to have a higher prevalence of periodontal diseases compared to healthy controls, possibly due to shared inflammatory mechanisms.
15 citations
,
April 2022 in “Immunology” This review discusses sex differences in immune responses to COVID-19 and highlights that males tend to experience more severe symptoms and higher mortality but reports no new clinical findings.
14 citations
,
March 2021 in “Journal of Pediatric and Adolescent Gynecology” In teens with Polycystic Ovary Syndrome and obesity, issues related to metabolism, skin, and mental health are common, and a clinic with various specialists can provide care for most of these problems.
7 citations
,
March 2020 in “Journal of King Saud University. Science/Maǧallaẗ ǧāmiʹaẗ al-malik Saʹūd. al-ʹUlūm” This study found that AiQingHua oil improved microcirculation and promoted hair regeneration in mice with testosterone-induced alopecia.
2 citations
,
March 2025 in “ESMO Open” In this extended follow-up of the PALOMA-2 trial, no significant differences in overall quality of life were observed between first-line treatments for metastatic breast cancer, but palbociclib plus letrozole showed some benefits regarding side-effects and hair loss.
1 citations
,
November 2022 in “International Journal of Molecular Sciences” This study observed that Kelulut honey effectively normalized the expression of certain sex steroid receptors in PCOS-induced rats, similar to metformin and clomiphene.
February 2025 in “IntechOpen eBooks” This chapter examines how hormonal changes during the postpartum period, alongside various external factors, impact mother and infant well-being, addressing challenges like postpartum depression, fatigue, and healthcare access, while stressing the need for improved medical training focused on maternal and fetal health.
January 2015 in “Hair transplant forum international” This abstract introduces a historical perspective on Dorothy Osborn's research about the hereditary nature of common baldness but reports no new study results.
96 citations
,
January 1997 in “Clinics in Dermatology” This study found that G protein-coupled estrogen receptor enhances melanin synthesis in melanoma cells through cAMP-PKA-MITF-TYR signaling, suggesting its potential as a drug target for chloasma treatment.
99 citations
,
December 2010 in “Journal of The European Academy of Dermatology and Venereology” This article discusses the association of acne with various systemic diseases, emphasizing the role of androgen steroids, insulin resistance, and inflammation in acne pathogenesis, but it reports no new clinical results.
27 citations
,
August 2010 in “Clinics in Dermatology” This article reviews the association between hepatitis C virus and systemic disorders like mixed cryoglobulinemia, highlighting potential autoimmune side effects from interferon-a2b treatments, and reports no new clinical results.
June 2024 in “Clinical Endocrinology and Metabolism” This article examines when it is appropriate to prescribe estrogen for women with hormonal imbalances, utilizing decades of clinical practice, expert consultation, and a comprehensive literature review.
25 citations
,
May 2003 in “Expert Opinion on Therapeutic Patents” This review examines patents and publications on steroid sulfatase inhibitors since 1999 and reports no new clinical results, highlighting their potential for treating estrogen- and androgen-driven conditions.
16 citations
,
September 1964 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that new compounds with anti-androgenic effects were found to counteract testosterone in animals without significant estrogenic activity, indicating potential for managing androgen-related conditions.
35 citations
,
July 2007 in “Dermatologic clinics” This review discusses the causes and diagnostic process for facial hypermelanosis, emphasizing the need to rule out systemic disorders like Addison's disease; it reports no new clinical findings.
31 citations
,
March 2015 in “The Journal of Steroid Biochemistry and Molecular Biology” This review discusses the complexity of neuroactive steroid therapies for neuroprotection and reports no new clinical findings, suggesting potential unexpected effects in the brain compared to systemic levels.
8 citations
,
November 2019 in “Dermatologic Clinics” This study highlights the importance of clinicians understanding the effects of gender-affirming hormones like testosterone, estrogen, and antiandrogens on hair growth, to effectively diagnose and treat androgenetic alopecia in gender minority patients.
March 2023 in “Revista Chilena de Urología” This review discusses post-finasteride syndrome, highlighting occasional adverse sexual and systemic effects in men and women, but reports no new research findings while emphasizing the need for better education about the drug's risks.
5 citations
,
July 2003 in “Drug Development Research” In this study, using a novel topical androgen receptor suppressor, fluridil, significantly increased the percentage of growing hairs in males with androgenetic alopecia without systemic absorption or adverse side effects.
50 citations
,
April 2014 in “Nature Communications” This study analyzed skin from 538 knockout mouse mutants and identified 50 with epidermal phenotypes, providing valuable insights into genetic conditions and systemic effects related to skin abnormalities.
9 citations
,
April 2021 in “Expert opinion on pharmacotherapy” This review highlights that clascoterone, a newly FDA-approved topical androgen antagonist, effectively reduces both non-inflammatory and inflammatory acne lesions with no systemic effects, making it a promising new option for acne treatment in both male and female patients.
9 citations
,
April 1986 in “Postgraduate Medicine” This article reviews the causes of hair loss in pediatric and adult populations, emphasizing the importance of distinguishing between primary dermatologic conditions and those related to systemic diseases, but reports no new clinical findings.
6 citations
,
January 2017 in “Dermato-endocrinology” This study found that androsterone glucuronate (ADT-G) was the only androgenic metabolite sensitive to detecting differences between adult women with acne and controls, and its levels decreased with systemic treatment.