Hormones and COVID-19

    April 2023 in “ Mayo Clinic Proceedings ”
    Andrew Elagizi, Carl J. Lavie, Felice L Gersh, James H. O’Keefe
    TLDR Estrogen may help improve COVID-19 outcomes, especially in women.
    The document discusses the potential impact of hormones on COVID-19 prognosis, highlighting differences between testosterone and estrogen. Testosterone may influence COVID-19 severity, with men on androgen deprivation therapy showing reduced infection risk and milder symptoms. However, a retrospective study found no significant difference in COVID-19 outcomes related to testosterone therapy. In contrast, estrogen, particularly estradiol (E2), is suggested to play a significant role in enhancing the female immune response, potentially offering benefits in managing COVID-19. The document suggests that E2 supplementation in menopausal women could enhance immune function, supporting survival and health longevity. The findings emphasize the potential of hormone replacement therapy in influencing COVID-19 outcomes, particularly in women.
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