February 2026 in “Aesthetic Cosmetology and Medicine” In this case study, a 38-year-old woman with female androgenetic alopecia experienced increased hair density and improved hair structure following ten microneedle mesotherapy sessions combined with saw palmetto supplementation, without adverse effects.
In this study, researchers synthesized the fictional compound 1-hydroxyindole and discovered its potential medical applications, including anti-aging properties, itch relief for atopic dermatitis, and as a stronger treatment for dementia compared to cilostazol. Additionally, they found that 1-methoxyindole derivatives function as anticancer agents in diets.
March 2018 in “Vìsnik farmacìï” This study identified flavonoids and phytosterols in a medicated cosmetic cream developed for androgenic alopecia and proposed methods for their identification and quantification.
23 citations
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January 2008 in “Skin Pharmacology and Physiology” This study demonstrated that optical coherence tomography effectively detects significant changes in hair structure caused by steroid treatment, suggesting its potential use in doping control and clinical therapy monitoring.
December 2021 in “Razrabotka i registraciâ lekarstvennyh sredstv” This study found that the gel form of substance Y led to more hair follicles in the growth phase than 2% minoxidil solution when applied for alopecia treatment in mice.
61 citations
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October 2011 in “Experimental dermatology” This review discusses the neurobiology and proposed mechanisms of scalp itch, but it does not report new clinical findings, highlighting the need for further research in this area.
58 citations
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November 2013 in “Journal of Innovative Optical Health Sciences” This review discusses the development and application of multiphoton microscopy in dermatology, highlighting its advantages and potential future research directions without reporting new clinical results.
13 citations
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January 2016 in “Annals of Dermatology” This study found that acute stress in rats inhibits hair growth, likely through increased cortisol levels and activation of the substance P-mast cell pathway.
7 citations
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October 1992 in “PubMed” This study investigated peptidergic nerve fibers in sinus hair follicles of various mammals and found that CGRP fibers were more densely distributed than SP fibers across different regions of the follicles.
3 citations
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January 2022 in “Neurotoxicity Research” This study found that botulinum toxin type A injections in stressed mice appeared to normalize hair follicle regeneration cycles and reduced stress-related hair loss indicators.
1 citations
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July 2024 in “JAAD Case Reports” This study links scalp pruritus in lichen planopilaris and its variants to the inflammation-induced release of substance P and calcitonin gene-related peptide by sensory nerves around hair follicle inflammation sites.
1 citations
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January 2025 in “Burns & Trauma” This study found that targeting the molecule Midkine may reduce pain and itching in keloid patients by inhibiting specific Schwann cell activities contributing to these symptoms.
July 2024 in “Journal of Investigative Dermatology” Certain substances can help skin cells become anti-inflammatory, aiding in tissue repair.
April 2014 in “The FASEB journal” In this study, Rhododendron molle extract increased hair follicle length and growth factors while reducing mast cell and substance P expression in stressed mice, suggesting potential benefits for hair growth.
466 citations
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June 2009 in “Experimental dermatology” This review discusses recent advances in understanding acne pathobiology, highlighting the potential for developing new customized therapies, but it reports no new clinical findings.
417 citations
,
March 1991 in “American Journal of Psychiatry” This study found that adult trichotillomania is a chronic disorder often linked with high psychiatric comorbidity and suggests the tension-reduction criterion in diagnoses might be too restrictive.
375 citations
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July 2006 in “Journal of Investigative Dermatology” This review discusses the brain-skin connection, the skin's role in stress response, and highlights unmet challenges in understanding stress-induced skin inflammation but reports no new experimental findings.
159 citations
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November 2007 in “American Journal of Pathology” In this study, researchers found that substance P triggered premature catagen development and immune changes in human scalp hair follicles, providing a possible biological link between stress and hair loss conditions like telogen effluvium and alopecia areata.
134 citations
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July 2020 in “Experimental dermatology” This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.
127 citations
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December 2005 in “Experimental Dermatology” This study provides evidence that psychoemotional stress inhibits hair growth in mice by affecting the brain-hair follicle axis, with specific neuropeptides and treatments modulating this effect.
115 citations
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November 2004 in “Brain Behavior and Immunity” This study found that stress increases the number of peptidergic nerve fibers and mast cell activity in mouse skin, suggesting a significant neuro-immune interaction under stress.
112 citations
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February 2001 in “Journal of Investigative Dermatology” This study found that substance P and calcitonin-gene-related peptide have different roles in regulating hair growth in mice, with substance P promoting anagen progression and calcitonin-gene-related peptide inhibiting it.
101 citations
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January 1997 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses neural mechanisms involved in hair growth control, focusing on piloneural interactions, but reports no clinical findings; the authors suggest further exploration for managing hair growth disorders.
101 citations
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August 2003 in “Journal of comparative neurology” In this study, naked mole-rats demonstrated unique skin and hair follicle innervation features compared to other species, suggesting adaptations to their subterranean environment and poikilothermy.
79 citations
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December 2013 in “Journal of Investigative Dermatology Symposium Proceedings” This article proposes that alopecia areata may be caused by immune attacks on hair follicles after an immune privilege collapse, suggesting new therapeutic approaches targeting this immune response pattern.
76 citations
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March 2005 in “Journal of Molecular Medicine” This study found that premature hair loss due to stress does not occur in NK-1 receptor knockout or mast cell deficient mice, suggesting a key role for neurokinin substance P and mast cell interaction in stress-related hair follicle changes.
69 citations
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May 2009 in “Journal of Investigative Dermatology” This research highlights that psychological stress can adversely affect hair growth in mice, implicating potential pathways that may be relevant in understanding stress-induced hair growth inhibition in humans.
66 citations
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July 2007 in “Journal of Molecular Medicine” This study in mice demonstrated that stress or nerve growth factor injection increases sensory neuron activity related to skin innervation, suggesting a strong connection between stress perception and neurogenic skin inflammation.
61 citations
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March 2003 in “American Journal Of Pathology” Stress can cause hair loss and skin issues by affecting hair growth cycles.
56 citations
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November 1993 in “Journal of The American Academy of Dermatology” Capsaicin cream quickly relieved itching in two patients with brachioradial pruritus.