Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

November 2012 in “ Biomolecules & therapeutics ”

Gyeoung Jin Kang, Sang‐Kyoo Han, Young Sang Koh, Hee Kyoung Kang, You Jin Jeon, Eun Sook Yoo

Diphlorethohydroxycarmalol Ishige okamurae prostaglandin E2 HaCaT human keratinocytes cyclooxygenase-1 cyclooxygenase-2 COX-1 COX-2 rofecoxib indomethacin DPHC PGE2 HaCaT cells

TLDR A compound from brown algae boosts the production of a certain inflammatory substance in skin cells.

The study investigated the effects of Diphlorethohydroxycarmalol (DPHC), a compound from the brown algae Ishige okamurae, on prostaglandin E2 (PGE2) synthesis in HaCaT human keratinocytes. It was found that DPHC significantly increased PGE2 production in a dose-dependent manner by upregulating the protein and mRNA levels of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), with COX-1 expression occurring before COX-2. Additionally, while both rofecoxib and indomethacin inhibited PGE2 production, indomethacin was more potent. These results suggest that DPHC may have beneficial effects through the enhancement of PGE2 production.