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    GlossaryCyclooxygenase-1 (COX-1)

    enzyme involved in producing compounds that regulate inflammation and protect stomach lining

    Cyclooxygenase-1 (COX-1) is an enzyme that plays a crucial role in the production of prostaglandins, which are lipid compounds that perform various functions in the body, such as regulating inflammation, protecting the stomach lining, and maintaining kidney function. Unlike its counterpart COX-2, which is typically induced during inflammation, COX-1 is constitutively expressed, meaning it is produced continuously in most tissues to maintain normal physiological processes.

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      community Correct way to microneedling, with existent hair

      in Microneedling  12 upvotes 1 year ago
      The conversation discusses the correct method of microneedling for hair loss, questioning whether it should be done on areas with long hair without risking hair damage, and if it's necessary for improving blood flow to existing hair. No specific treatments were mentioned.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 1 year ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

      community Painkillers May Block Minoxidil

      in Research/Science  14 upvotes 11 months ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

      community Who won’t respond to minoxidil? (Studies)

      in Research/Science  32 upvotes 1 week ago
      Minoxidil's effectiveness varies due to differences in sulfotransferase enzyme levels in the scalp, affecting people with conditions like ASD, liver disease, and androgenic alopecia. Treatments like topical tretinoin, microneedling, and using minoxidil sulfate instead of regular minoxidil can improve results for those with low enzyme levels.