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Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

research Diphlorethohydroxycarmalol, Isolated from Ishige okamurae, Increases Prostaglandin E₂through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

9 citations , November 2012 in “Biomolecules & therapeutics”

This study found that diphlorethohydroxycarmalol significantly increased prostaglandin $E_2$ synthesis in HaCaT human keratinocytes by upregulating COX-1 and COX-2 expression, suggesting potential benefits from elevated $PGE_2$ production.

research Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways

March 2026 in “Molecules”

In this laboratory study, researchers reported that Camellia sinensis seed flavonoids significantly reduced oxidative stress and inflammation in UV-irradiated skin cells by modulating key signaling pathways, highlighting its potential as a skincare ingredient for anti-inflammatory and anti-photoaging benefits.

research Chemical Constituents from Osmanthus fragrans var. aurantiacus Makino with Their In Vitro and In Silico Studies Target Anti-Inflammation by Suppressing ERK 1/2 MAPK Signaling

August 2025 in “International Journal of Molecular Sciences”

This study found that compounds isolated from Osmanthus fragrans var. aurantiacus demonstrated antioxidative and anti-inflammatory activities, potentially offering therapeutic benefits for inflammatory bowel diseases by inhibiting COX-2 and iNOS enzymes and blocking ERK 1/2 MAPK signaling.

research Anti-inflammatory, cyclooxygenase inhibitory and antioxidant activities of standardized extracts of Tridax procumbens L.

61 citations , September 2010 in “Fitoterapia”

This study found that the EtOAc extract of Tridax procumbens aerial parts significantly inhibited rat paw edema and COX enzyme activity, suggesting its potential anti-inflammatory properties.

research Hypersensitivity Reactions to Anticoagulant Drugs

28 citations , September 2008 in “Current Pharmaceutical Design”

This review discusses hypersensitivity reactions to anticoagulants like ASA and heparins, highlighting their rare but potentially life-threatening nature, and emphasizes the need for meticulous allergy testing to find safe alternatives.

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Community Join

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community Painkillers May Block Minoxidil

12 upvotes 1 year ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

3 upvotes 1 year ago

DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

community 35M, been on Finasteride for 12 years, oral min 5mg 2 years no HT

1204 upvotes 4 months ago

A 35-year-old man has used finasteride for 12 years and oral minoxidil at 5 mg for 2 years, achieving significant hair regrowth and density without side effects, avoiding a hair transplant. He recommends consistency with medication and highlights the effectiveness and affordability of oral minoxidil.

community Topical melatonin shows some promise.

4 upvotes 10 years ago

Topical melatonin shows promise for increasing hair density with minimal side effects. The user is transitioning from oral finasteride to a compounded minoxidil and finasteride solution and considering melatonin and bimatoprost as additional treatments.

community Sexual Dysfunction in Those with Androgenetic Alopecia on Dutasteride Versus Finasteride

in Finasteride/Dutasteride 113 upvotes 1 year ago

Dutasteride and finasteride have similar risks of sexual dysfunction for treating androgenetic alopecia. Users experience varying side effects, indicating individual differences in drug reactions.

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Hair Transplant Surgeon
Dr. Surget Cox, MD
Metairie, LA, United States

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Dr. Surget Cox, MD