Camellia Sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways
March 2026
in “
Molecules
”
Camellia sinensis seed flavonoids UVB-induced inflammation UVA-induced photodamage MAPK pathway NF-κB pathway AP-1 pathway reactive oxygen species p38/JNK pathway iNOS COX-2 keratinocytes Caspase-3 barrier proteins fibroblasts collagen hyaluronic acid TGF-β/Smad pathway anti-inflammatory barrier-repair anti-photoaging green tea seed flavonoids skin inflammation skin photodamage ROS skin barrier proteins skin collagen skin hyaluronic acid skin anti-aging
This study investigated the effects of Camellia sinensis seed flavonoids (CSF) on UVB-induced inflammation and UVA-induced photodamage in human skin cells. CSF was found to significantly reduce reactive oxygen species (ROS) and inflammatory factors by inhibiting the p38/JNK and NF-κB pathways, as well as iNOS and COX-2 expression. In keratinocytes, CSF downregulated Caspase-3 and upregulated barrier proteins, while in fibroblasts, it enhanced collagen and hyaluronic acid production by modulating the AP-1 and TGF-β/Smad pathways. These findings suggest that CSF has potential as a skincare ingredient due to its anti-inflammatory, barrier-repair, and anti-photoaging properties.
