research Camellia Sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways
This study investigated the effects of Camellia sinensis seed flavonoids (CSF) on UVB-induced inflammation and UVA-induced photodamage in human skin cells. CSF was found to significantly reduce reactive oxygen species (ROS) and inflammatory factors by inhibiting the p38/JNK and NF-κB pathways, as well as iNOS and COX-2 expression. In keratinocytes, CSF downregulated Caspase-3 and upregulated barrier proteins, while in fibroblasts, it enhanced collagen and hyaluronic acid production by modulating the AP-1 and TGF-β/Smad pathways. These findings suggest that CSF has potential as a skincare ingredient due to its anti-inflammatory, barrier-repair, and anti-photoaging properties.
