Plasma Diaphanous Related Formin 1 Levels Are Associated with Altered Glucose Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Case Control Study

    February 2022 in “ Mediators of Inflammation ”
    Xing Li, Mingyu Liao, Jianghua Shao, Weixin Li, Liu Shi, Dong Wang, Juan Ni, Qiuyue Shen, Fan Yang, Guiliang Peng, Ling Zhou, Yuling Zhang, Zheng Sun, Cong-Yi Wang, Min Long
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    TLDR Women with Polycystic Ovary Syndrome (PCOS) have lower levels of a substance called DIAPH1 in their blood, which is linked to changes in sugar metabolism and insulin resistance.
    The research involved 152 participants, 75 with Polycystic Ovary Syndrome (PCOS) and 77 healthy individuals. It was found that plasma Diaphanous Related Formin 1 (DIAPH1) levels were significantly lower in women with PCOS, especially those who were overweight. DIAPH1 levels were also associated with fasting blood glucose, total cholesterol, β-cell function, and hormone ratios. The study concluded that DIAPH1 levels are an independent risk factor for PCOS and could be used as a predictive factor. A model was created to predict PCOS risk, including DIAPH1, BMI, fasting blood glucose, and testosterone, with a sensitivity of 92.0% and a specificity of 80.9%.
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