TLDR Women with Polycystic Ovary Syndrome (PCOS) have lower levels of a substance called DIAPH1 in their blood, which is linked to changes in sugar metabolism and insulin resistance.
The research involved 152 participants, 75 with Polycystic Ovary Syndrome (PCOS) and 77 healthy individuals. It was found that plasma Diaphanous Related Formin 1 (DIAPH1) levels were significantly lower in women with PCOS, especially those who were overweight. DIAPH1 levels were also associated with fasting blood glucose, total cholesterol, β-cell function, and hormone ratios. The study concluded that DIAPH1 levels are an independent risk factor for PCOS and could be used as a predictive factor. A model was created to predict PCOS risk, including DIAPH1, BMI, fasting blood glucose, and testosterone, with a sensitivity of 92.0% and a specificity of 80.9%.
189 citations,
March 2018 in “Human Reproduction Update” Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.
4025 citations,
December 2003 in “Human Reproduction” The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.
[object Object]
1514 citations,
December 2011 in “Fertility and sterility” Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.
317 citations,
April 2018 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.
[object Object] 62 citations,
October 2019 in “Liver International” Women with PCOS have more severe liver disease.
58 citations,
January 2013 in “The Journal of Clinical Endocrinology and Metabolism” Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.
48 citations,
February 2008 in “Nutrition in Clinical Practice” Dietary changes, including weight loss and a balanced diet, are important for managing PCOS, especially in overweight women.
