TLDR Women with Polycystic Ovary Syndrome (PCOS) have lower levels of a substance called DIAPH1 in their blood, which is linked to changes in sugar metabolism and insulin resistance.
The research involved 152 participants, 75 with Polycystic Ovary Syndrome (PCOS) and 77 healthy individuals. It was found that plasma Diaphanous Related Formin 1 (DIAPH1) levels were significantly lower in women with PCOS, especially those who were overweight. DIAPH1 levels were also associated with fasting blood glucose, total cholesterol, β-cell function, and hormone ratios. The study concluded that DIAPH1 levels are an independent risk factor for PCOS and could be used as a predictive factor. A model was created to predict PCOS risk, including DIAPH1, BMI, fasting blood glucose, and testosterone, with a sensitivity of 92.0% and a specificity of 80.9%.
189 citations
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March 2018 in “Human Reproduction Update” Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.
4025 citations
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December 2003 in “Human Reproduction” The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.
April 2021 in “Interciencia médica” PCOS is a common condition in women that causes various symptoms and health issues, treatable with lifestyle changes and medication.
28 citations
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January 2017 in “Obstetrician & gynaecologist/The obstetrician & gynaecologist” The document concludes that managing PCOS effectively requires considering ethnic differences, obesity's impact, and ethical concerns in treatment approaches.
2 citations
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November 2019 in “Journal für Klinische Endokrinologie und Stoffwechsel” PCOS is a common hormonal disorder in women, treated with lifestyle changes and hormonal therapy.
40 citations
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January 2010 in “Annales D Endocrinologie” The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.
January 2023 in “International journal of clinical medicine” Women with PCOS and hair loss have lower levels of the protein gelsolin in their blood.
