Ethanol Extract of Sinsun-Yukza-Hwan Promotes Hair Growth in C57BL/6 Mice, an Alopecia Animal Model

The study investigated the transdermal effects of the ethanol extract from Sinsun-yukza-hwan (SSY) on hair growth in C57BL/6 mice, an alopecia model. The SSY extract, containing 5-hydroxy-methyl-2-furaldehyde (HMF), was applied daily for 15 days. Results showed that both SSY and minoxidil significantly increased hair density and thickness compared to the vehicle group. Additionally, SSY extract significantly accelerated the expression of hair growth-associated genes, including IGF-1 and VEGF. These findings provided scientific evidence supporting SSY's potential as a cosmeceutical material for promoting hair growth.