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CRISPR/Cas9 gene-editing shows promise for improving sheep and goat breeding but faces challenges with efficiency and accuracy.

Hoxc13 gene affects wool length in Gansu alpine fine-wool sheep.

Human skin xenografting could improve our understanding of skin development, renewal, and healing.

Hairlessness in mammals is due to complex genetic changes in both genes and regulatory regions.

Not getting enough minerals can lead to health problems and shorter lifespans.

Trichotillomania in dementia may be better treated with dopamine blockers like quetiapine than with SSRIs.

Aging slows wound healing due to weaker cells and immune response.

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.

Repurposing existing drugs can improve cancer treatment but faces challenges.

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

The conclusion is that women under 35 should start fertility checks after 12 months of trying to conceive, women over 35 after 6 months, and women over 40 should start immediately. The checks should include ovulation status, reproductive tract structure, and male partner's semen evaluation.

TCF/Lef1 is essential for skin barrier function by regulating lipid metabolism.

Transglutaminase activity is important for skin and is found in both mammals and birds.

Isotretinoin therapy for acne can cause many reversible side effects, mainly mild skin conditions, and patient understanding of these effects can improve treatment adherence.

The HtrA1L364P mutation causes brain dysfunction and blood vessel damage.

A young Russian girl with Meier-Gorlin syndrome has two new mutations in the CDC6 gene.

A girl with skin rashes and low zinc levels improved with zinc supplements and had new gene mutations linked to her condition.

ACBP is crucial for healthy skin in mice.

Myotonic Dystrophy may age cells faster, and drugs that target aging could be potential treatments.

Mesenchymal stem cells could help treat aging-related diseases better than current methods.

Spironolactone nano-formulations show promise for treating skin disorders, but more research is needed for safety and effectiveness.

Drug repurposing speeds up development, cuts costs, and uses known safe drugs, but faces challenges like regulations and patents.

Cirrhosis affects quality of life with various symptoms, requiring a holistic, multidisciplinary approach for management.

Vitiligo causes white skin patches, often starts before age 20, and is linked to other health issues.

The document concludes that more multidisciplinary research is needed to understand and treat PCOS, a condition that significantly affects women's health and quality of life.

Targeted anticancer therapies can cause severe side effects similar to traditional chemotherapy, but with different types.

Metabolic Syndrome is linked to several skin conditions, and stem cell therapy might help treat them.

PCOS affects fertility and is linked to obesity and menstrual irregularities; lifestyle changes are recommended for treatment.