Review of Drug Repositioning in Cancer Therapeutics

    August 2024 in “ Asian Journal of Research in Chemistry ”
    Seema B. Kharwade, Dipti B. Ruikar, Snehal S. Manekar, Nikita P. Shahane
    From the encyclopedia
    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Metformin →

    diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

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    Studysummary This source concludes that repurposing existing drugs, such as using metformin with other treatments in advanced non-small cell lung cancer, may enhance cancer patient outcomes, although various technical and legal challenges need addressing. Our plain-language summary of this paper — not a Tressless recommendation.
    The review explores drug repositioning in cancer therapeutics, focusing on the potential of repurposing existing drugs to enhance cancer treatment outcomes. It highlights Minoxidil as a drug with an on-target profile for hair loss and Metformin's promise in improving progression-free survival in non-small cell lung cancer when combined with other treatments. Thalidomide, despite its teratogenic effects, can boost the immune system to combat cancer by increasing IL-2 secretion. The review underscores the benefits of combining repurposed drugs with other treatments but acknowledges the technological and legal challenges that must be addressed.
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