Review of Drug Repositioning in Cancer Therapeutics

    August 2024 in “ Asian Journal of Research in Chemistry ”
    Seema B. Kharwade, Dipti B. Ruikar, Snehal S. Manekar, Nikita P. Shahane
    TLDR Repurposing existing drugs can improve cancer treatment but faces challenges.
    The review explores drug repositioning in cancer therapeutics, focusing on the potential of repurposing existing drugs to enhance cancer treatment outcomes. It highlights Minoxidil as a drug with an on-target profile for hair loss and Metformin's promise in improving progression-free survival in non-small cell lung cancer when combined with other treatments. Thalidomide, despite its teratogenic effects, can boost the immune system to combat cancer by increasing IL-2 secretion. The review underscores the benefits of combining repurposed drugs with other treatments but acknowledges the technological and legal challenges that must be addressed.
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