Drug Repurposing in Dermatology: Molecular Biology and Omics Approach

    August 2020 in “ IntechOpen eBooks ”
    Farid A. Badria, Abdullah A. Elgazar
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    TLDR Old drugs like finasteride and spironolactone are being successfully used for hair loss and skin conditions, and many other drugs show promise for new uses in dermatology.
    The document discusses the potential of drug repurposing in dermatology, particularly for conditions like alopecia, psoriasis, acne, hirsutism, and hyperpigmentation. It highlights the successful repositioning of drugs like finasteride for androgenic alopecia and spironolactone for polycystic ovary syndrome and hirsutism. The document also presents findings on the effects of various drugs on hair loss and growth. For instance, oral valproate can induce hair loss, while its topical application can promote hair growth. Other drugs like minoxidil, originally for hypertension, have been repurposed for hair regrowth in androgenic alopecia patients. The document also mentions other drugs like Bimatoprost, Phenytoin, Bevacizumab, Tofacitinib, Metformin, Niclosamide, Beta-blockers, and Cannabidiol, which have potential for new applications in dermatology.
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      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community My scalp punch biopsy results🤔?

      in Female  8 upvotes 1 year ago
      Female using Rogaine foam for hair loss had scalp punch biopsy, diagnosed with Androgenetic Alopecia (AGA). Doctor recommended starting Spironolactone 50mg.

      community having hair loss as a teen SUCKS. A LOT.

      in Female  12 upvotes 2 years ago
      A teenage girl who has been diagnosed with ADA and is struggling with hair loss, which has caused her to lose confidence. She is looking for recommendations on treatments such as finasteride or Minoxidil, and lifestyle advice including vitamins and other supplements that might help with the issue.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community For the ladies: Spironolactone for FPHL

      in Female  12 upvotes 7 years ago
      A 34 year old female with androgenic alopecia who has tried treatments such as Spironolactone, Desogen, Minoxidil and Finasteride in order to address her hair loss. It also details the experiences of other women taking Spironolactone for Female Pattern Hair Loss (FPHL).

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