Drug Repurposing in Dermatology: Molecular Biology and Omics Approach

    August 2020 in “ IntechOpen eBooks ”
    Farid A. Badria, Abdullah A. Elgazar
    Image of study
    TLDR Old drugs like finasteride and spironolactone are being successfully used for hair loss and skin conditions, and many other drugs show promise for new uses in dermatology.
    The document discusses the potential of drug repurposing in dermatology, particularly for conditions like alopecia, psoriasis, acne, hirsutism, and hyperpigmentation. It highlights the successful repositioning of drugs like finasteride for androgenic alopecia and spironolactone for polycystic ovary syndrome and hirsutism. The document also presents findings on the effects of various drugs on hair loss and growth. For instance, oral valproate can induce hair loss, while its topical application can promote hair growth. Other drugs like minoxidil, originally for hypertension, have been repurposed for hair regrowth in androgenic alopecia patients. The document also mentions other drugs like Bimatoprost, Phenytoin, Bevacizumab, Tofacitinib, Metformin, Niclosamide, Beta-blockers, and Cannabidiol, which have potential for new applications in dermatology.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 1000+ results

      community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

      in Progress Pictures  224 upvotes 1 year ago
      A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  56 upvotes 2 years ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community For the ladies: Spironolactone for FPHL

      in Female  11 upvotes 9 years ago
      A 34 year old female with androgenic alopecia who has tried treatments such as Spironolactone, Desogen, Minoxidil and Finasteride in order to address her hair loss. It also details the experiences of other women taking Spironolactone for Female Pattern Hair Loss (FPHL).

      community Topical Spironolactone 5% effectiveness

      in Product  2 upvotes 1 year ago
      Topical spironolactone 5% is being discussed for its effectiveness in treating hair loss, specifically receding temples. The user is inquiring if it works similarly to finasteride as a testosterone blocker.

      community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

      in Female  42 upvotes 4 years ago
      User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.

      community Dont fucking wait to start finasteride!

      in Chat  372 upvotes 4 years ago
      User baldwarrior85 regrets not starting finasteride earlier to prevent hair loss. Others share their experiences, with some having side effects and others seeing positive results from the treatment.

    Similar Research

    5 / 1000+ results