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    Glossary Stratum Corneum

    outermost skin layer composed of dead, keratinized cells

    The Stratum Corneum, also known as the Horny Layer, is the outermost layer of the epidermis, consisting of dead, flattened skin cells that are rich in keratin. This layer acts as a primary barrier to protect underlying tissues from infection, dehydration, and mechanical stress, playing a crucial role in maintaining skin hydration and overall health.

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    1. Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice Journal of Investigative Dermatology · 2003 · 216 citations
    2. LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery Journal of Lipid Research · 2011 · 211 citations
    3. Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream European journal of pharmaceutics and biopharmaceutics · 2007 · 132 citations
    4. Terbinafine levels in serum, stratum corneum, dermis-epidermis (without stratum corneum), hair, sebum and eccrine sweat. Acta dermato-venereologica · 1991 · 121 citations
    5. Stratum corneum dysfunction in dandruff International Journal of Cosmetic Science · 2012 · 93 citations
    6. Corneodesmosomes and corneodesmosin: from the stratum corneum cohesion to the pathophysiology of genodermatoses European Journal of Dermatology · 2011 · 83 citations
    7. Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro Journal of Pharmaceutical Sciences · 2009 · 55 citations
    8. Functional analysis of the stratum corneum of scalp skin: studies in patients with alopecia areata and androgenetic alopecia Archives of Dermatological Research · 2000 · 52 citations
    9. Trichohyalin: Presence in the Granular Layer and Stratum Corneum of Normal Human Epidermis 1991 · 48 citations
    10. Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes Experimental Dermatology · 2019 · 44 citations
    11. Non-invasive analysis of penetration and storage of Isoconazole nitrate in the stratum corneum and the hair follicles European Journal of Pharmaceutics and Biopharmaceutics · 2012 · 17 citations
    12. In vivo penetration of bare and lipid-coated silica nanoparticles across the human stratum corneum Colloids and surfaces. B, Biointerfaces · 2014 · 16 citations
    13. The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions International Journal of Molecular Sciences · 2022 · 11 citations
    14. Analysis of the Pretreatment Effect of Ethanol on the Stratum Corneum- and Hair Follicular-Penetration of Drugs Using the Hair Follicle-Plugging Method Chemical and Pharmaceutical Bulletin · 2014 · 10 citations
    15. Characterization of Soluble Protein Extracts from Keratinized Tissues: identification of Ubiquitin Universally Distributed in Hair, Nail, and Stratum Corneum Bioscience Biotechnology and Biochemistry · 2001 · 10 citations
    16. Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure Langmuir · 2023 · 9 citations
    17. The stratum corneum barrier: impaired function in relation to associated lipids and proteins Tissue Barriers · 2024 · 7 citations
    18. Morphological Studies of Penetration Pathways via Stratum corneum and Hair Follicles using Nano-sized Iron Oxide Microscopy and Microanalysis · 2017 · 1 citations
    19. 601 A quantitative study of desquamation in the stratum corneum Journal of Investigative Dermatology · 2023
    20. Nanostructured lipid carriers (NLCs) composed of argan oil, the potential novel vehicle for caffeine delivery to stratum corneum and hair follicles DOAJ (DOAJ: Directory of Open Access Journals) · 2022
    21. In vivo silica nanoparticle translocation across human stratum corneum: the effect of surface hydrophobization in relation to hair follicle density. IRIS UNIMORE (University of Modena and Reggio Emilia) · 2013
    22. Development of Stratum Corneum Lipid Liposomes for Topical Drug Delivery International Journal of Drug Delivery Technology · 2026
    23. Enhancement of drug permeation across skin through stratum corneum ablation RSC pharmaceutics · 2024
    24. Functional analyses of the stratum corneum of scalp skin : Studies in patients with alopecia areata and androgenetic alopecia 2001
    25. Identification of autophagy-regulated proteins by proteomic analysis of tape-stripped stratum corneum Archives of Dermatological Research · 2024
    26. 1299 Live imaging of keratin network in stratum granulosum reveals dynamic cytoskeletal changes during cornification in mice in vivo Journal of Investigative Dermatology · 2018
    27. Variations of Hair Follicle Size and Distribution in Different Body Sites Journal of Investigative Dermatology · 2004 · 405 citations
    28. Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications Frontiers in Bioengineering and Biotechnology · 2021 · 365 citations
    29. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting Journal of controlled release · 2005 · 297 citations
    30. Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo Journal of biomedical optics · 2008 · 264 citations