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Glossary Steatocystoma Multiplex

Steatocystoma multiplex is a genetic skin condition characterized by the development of multiple sebaceous cysts, which are benign lumps filled with sebum. While primarily affecting the skin, its relevance to hair loss lies in the fact that these cysts can occur in areas with hair follicles, potentially leading to localized inflammation or scarring that may impact hair growth. Key distinguishing characteristics include the presence of multiple cysts, often appearing in adolescence or early adulthood, and their tendency to be asymptomatic, although they can become inflamed or infected.

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research Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2

175 citations , September 1998 in “British Journal of Dermatology”

This study found that mutations in the K17 gene underlie both pachyonychia congenita type 2 and steatocystoma multiplex phenotypes, regardless of the specific mutation involved.

research Clinical and Histologic Features of 64 Cases of Steatocystoma Multiplex

84 citations , March 2002 in “The Journal of Dermatology”

This study supports the idea that steatocystoma multiplex is a hamartomatous condition and suggests it may be a variant of eruptive vellus hair cyst, both originating in the pilosebaceous duct.

research Persistent Milia, Steatocystoma multiplex and Eruptive Vellus Hair Cysts: Variable Expression of Multiple Pilosebaceous Cysts within an Affected Family

39 citations , January 1998 in “Dermatology”

The authors concluded that milia, steatocystoma multiplex, and eruptive vellus hair cysts may be subtypes of multiple pilosebaceous cysts with overlapping histologic features.

research A Case of Steatocystoma Multiplex in a Psoriatic Patient during Treatment with Anti-IL-12/23

2 citations , January 2020 in “Skin Appendage Disorders”

This report presents a case where multiple steatocystomas appeared in a psoriatic patient during ustekinumab treatment, suggesting the drug may unmask a genetic predisposition to steatocystoma multiplex.

research Steatocystoma Multiplex

1 citations , December 2023 in “Indian Dermatology Online Journal”

The authors concluded that steatocystoma multiplex is a rare dermatological condition with poor treatment outcomes, emphasizing the importance of early recognition and psychological support for affected individuals.

research Steatocystomas: Update on Clinical Manifestations, Diagnosis, and Management

October 2025 in “Cutis”

This review provides an overview of the etiology, presentation, and diagnosis of steatocystomas, including subtypes and complications, while detailing their history, epidemiology, and management strategies.

research Keratin 17 null mice exhibit age- and strain-dependent alopecia

122 citations , June 2002 in “Genes & Development”

This study found that K17 is crucial for the structural integrity and survival of hair-producing cells, with K17 null mice developing alopecia due to hair fragility and follicular alterations.

research The keratins and their disorders

53 citations , September 2004 in “American journal of medical genetics. Part C, Seminars in medical genetics”

This review discusses the range of diseases caused by mutations in keratin intermediate filament genes and presents no new clinical findings; the authors note the diverse phenotypes within this molecular category.

research Eruptive vellus hair cyst: An uncommon and underdiagnosed entity

10 citations , January 2018 in “International journal of trichology”

This case report highlights the importance of histopathological examination in accurately diagnosing eruptive vellus hair cyst due to its rarity and resemblance to other conditions.

research An updated review of the sebaceous gland and its role in health and diseases Part 2: Pathophysiological clinical disorders of sebaceous glands

7 citations , February 2021 in “Dermatologic Therapy”

This review discusses various pathologies involving sebaceous glands, primarily and secondarily, but reports no new clinical findings.

research Timed exposure 10,600 nm CO2 laser drilling in various benign dermal tumours

1 citations , July 2015 in “European Journal of Dermatology”

This article discusses timed exposure settings with ablative lasers for treating benign dermal tumors and highlights their potential to reduce treatment time and scarring risk, but it reports no new clinical results.

research Cutaneous Keratocyst and Steatocystoma Unified as Sebaceous Duct Cyst, a Hamartoma Resembling the Sebaceous Duct

8 citations , July 2014 in “American Journal of Dermatopathology”

This discussion reviews the classification and naming of cutaneous cysts, proposing that cysts typically named cutaneous keratocyst and steatocystoma should be unified under the term "sebaceous duct cyst," but it reports no new clinical results.

research Sebaceous gland diseases: clinical picture risk factors and treatment

September 2023 in “International Journal of Community Medicine and Public Health”

This source reviews a range of sebaceous gland disorders, exploring their clinical characteristics, risk factors, and common treatments, including conditions such as sebaceous gland hyperplasia and acne vulgaris, and highlighting various therapeutic approaches.

research Keratin 17 in disease pathogenesis: from cancer to dermatoses

62 citations , October 2018 in “Journal of pathology”

This review discusses the mechanisms of keratin 17 regulation in diseases such as psoriasis and cancers but presents no new experimental findings, calling for further exploration of anti-K17 therapies.

research Delayed-onset pachyonychia congenita caused by a novel mutation in the V2 domain of keratin 6b

4 citations , December 2013 in “The Journal of Dermatology”

This letter to the editor discusses a case of delayed-onset pachyonychia congenita linked to a new mutation in keratin 6b but presents no new research findings.

research Cutaneous Adnexal Cysts Revisited: What We Know and What We Think We Know

13 citations , June 2018 in “Dermatopathology”

This classification proposal introduces a novel system for categorizing cutaneous adnexal cysts based on their origin in the folliculosebaceous unit and sweat glands, aiming to simplify and enhance understanding of these skin lesions.

research Baker′s dozen on the scalp: An interesting case of multiple trichilemmal cyst

5 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

A woman had 13 non-cancerous cysts on her scalp successfully removed in one surgery.

research Clinicopathologic Case 2: Multiple Intraoral White Lesions in a 55-year-old Female

April 2024 in “Oral Surgery Oral Medicine Oral Pathology and Oral Radiology”

In this case report, the patient was diagnosed with oral lichen sclerosus following a detailed clinical and histological examination and referral to dermatology, and it underscores the importance of interdisciplinary collaboration in managing this rare condition and its associated risks.

research Multicentric calcified trichilemmal cysts with alopecia universalis affecting siblings

9 citations , December 2012 in “Indian Journal of Dermatology Venereology and Leprology”

This study reports a rare case of a 40-year-old woman with multiple calcified trichilemmal cysts, associated with alopecia universalis and suggesting a potential genetic link.

research SkIndia Quiz 24: Itchy papules over face

January 2016 in “Indian Dermatology Online Journal”

This case study discusses a 36-year-old female diagnosed with a facial variant of eruptive vellus hair cyst, confirmed by skin biopsy, and highlights the importance of considering this condition in the differential diagnosis of asymptomatic facial papules.

research Eruptive vellus hair cysts: An underdiagnosed entity

2 citations , January 2022 in “International journal of trichology”

This case report details a rare instance of eruptive vellus hair cysts in a 12-year-old male, highlighting its atypical morphology and axillary distribution, which has not been previously documented.

research Management of hidradenitis suppurativa

4 citations , June 2002 in “Clinical and experimental dermatology”

This review discusses current treatments and management strategies for hidradenitis suppurativa, noting the mixed effectiveness of various therapies, including surgery, antibiotics, and hormonal treatments, but reports no new clinical findings.

research Advanced glycation end-products inhibit mesenchymal-epidermal interaction by up-regulating proinflammatory cytokines in hair follicles

3 citations , July 2015 in “European Journal of Dermatology”

This abstract discusses the role of advanced glycation end-products in aging-related skin damage, but does not provide new findings on their impact on alopecia.

research An updated review of the sebaceous gland and its role in health and diseases Part 1: Embryology, evolution, structure, and function of sebaceous glands

13 citations , December 2020 in “Dermatologic Therapy”

This review discusses the embryology, structure, and function of sebaceous glands and their involvement in skin disorders but reports no novel findings.

research The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16

53 citations , September 1999 in “The journal of cell biology/The Journal of cell biology”

In this study, expressing human K16 in the epidermis of K14 null mice prevented early skin blistering but led to age-related anomalies, indicating K16 and K14 have distinct roles despite their sequence similarity.

research Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology

22 citations , October 2020 in “Anais Brasileiros de Dermatologia”

This consensus concluded that oral isotretinoin is highly effective for treating acne and some off-label conditions, with common adverse events being manageable and rare serious risks not contraindicating use.

research Molecular pathology of skin adnexal tumours

16 citations , July 2021 in “Histopathology”

This review discusses recent findings on molecular changes in cutaneous adnexal tumours and reports novel markers and pathways involved, highlighting the diverse oncogenic drivers and tumour suppressor alterations.

research A Case Report of Sebaceous Filaments

November 2023 in “Curēus”

In this case report, a 16-year-old African American girl with sebaceous filaments on her face was successfully treated with topical tretinoin, highlighting the importance of recognizing and treating this under-reported condition for improved appearance and quality of life.

research Inherited Disorders of the Hair

2 citations , January 2013 in “Elsevier eBooks”

The document explains the genetic causes and characteristics of inherited hair disorders.

research Keratin disorders: from gene to therapy

109 citations , September 2011 in “Human molecular genetics online/Human molecular genetics”

This review discusses keratin disorders and potential RNA interference therapeutics, reporting no new clinical findings but highlighting the promise of siRNA for future treatments.