A Case of Steatocystoma Multiplex in a Psoriatic Patient During Treatment with Anti-IL-12/23

January 2020 in “ Skin Appendage Disorders ”

Claudio Marasca, Matteo Megna, Marianna Donnarumma, Giuseppina Fontanella, Eleonora Cinelli, Gabriella Fabbrocini

steatocystoma multiplex psoriasis ustekinumab IL-12/IL-23 inhibitor keratin 17 gene KRT17 interferon-γ IL-17 IL-22 Stelara

TLDR Ustekinumab treatment may reveal a genetic tendency for steatocystoma multiplex in psoriasis patients.

The document reported a case of steatocystoma multiplex (SM) in a psoriatic patient undergoing treatment with ustekinumab, an IL-12/IL-23 inhibitor. SM is characterized by multiple asymptomatic cutaneous cysts and is linked to a mutation in the keratin 17 gene (KRT17). The authors hypothesized that ustekinumab might have revealed a genetic predisposition to SM by reducing the expression of interferon-γ and IL-17/IL-22, thereby affecting the K17 pathway.

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