TLDR Ustekinumab might work for severe psoriasis, but more research is needed to be sure.
The 2012 document reviews the use of ustekinumab, a monoclonal antibody, for treating challenging forms of regional psoriasis, including palmoplantar, nail, and scalp psoriasis. It indicates that while there are some reports of ustekinumab's potential efficacy, the number of patients treated is too limited to draw definitive conclusions, and further research is needed to assess its cost-effectiveness and risk-benefit ratio. The document also discusses the unknown causes of regional psoriasis, the importance of individualized treatment plans, and the potential effectiveness of ustekinumab in both biologic-naive patients and those who have not responded to other biotherapies. It highlights the need to consider the psychological impact of psoriasis and the challenges of comparing drugs due to the personalized nature of treatment.
51 citations,
January 2004 in “Skin Pharmacology and Physiology” The document explains hair growth and shedding, factors affecting it, and methods to evaluate hair loss, emphasizing the importance of skin biopsy for diagnosis.
14 citations,
December 2003 in “International Journal of Cosmetic Science” Hair growth and shedding are linked and can be disrupted, causing a delay known as the hair eclipse phenomenon, which is common in certain hair conditions and could lead to new treatments.
56 citations,
January 2001 in “Dermatology” Teloptosis is a key point in hair loss that could help in creating prevention-focused hair care strategies.
59 citations,
June 2022 in “Frontiers in medicine” There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.
6 citations,
January 2023 in “International journal of molecular sciences” Mast cells and CD8 T cells interact closely in skin diseases, affecting each other's behavior and contributing to conditions like psoriasis and eczema.
191 citations,
May 2018 in “British journal of dermatology/British journal of dermatology, Supplement” Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.
148 citations,
December 2018 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
48 citations,
April 2021 in “Journal of the American Academy of Dermatology” Topical corticosteroids are the best initial treatment for children's alopecia areata.
