Multicentric Calcified Trichilemmal Cysts With Alopecia Universalis Affecting Siblings

This case report described a rare occurrence of multicentric calcified trichilemmal cysts with alopecia universalis in a 40-year-old female and her sister, suggesting a possible genetic link. The patient presented with multiple cysts on the scalp, forearms, and buttocks, along with non-scarring hair loss across the entire body since childhood. Histopathological examination confirmed trichilemmal cysts with dystrophic calcification. The familial nature of the condition indicated a potential autosomal-dominant inheritance, although the exact genetic pattern was unclear. The case was notable for the association of trichilemmal cysts with alopecia universalis, a combination not previously documented, raising questions about a possible variant of FLOTCH syndrome or a unique pathological link.