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This study reports a rare case of a 40-year-old woman with multiple calcified trichilemmal cysts, associated with alopecia universalis and suggesting a potential genetic link.

This study identified specific germline and somatic mutations in the Phospholipase C Delta 1 gene as high-risk factors for developing hereditary trichilemmal cysts, involving a monoallelic two-hit mechanism.

This study found that cutaneous cysts most frequently appeared as epidermal cysts, with unusual locations posing diagnostic challenges that required histopathological analysis for definitive diagnosis.

This study reported that age and diabetes are major factors influencing trichilemmal cyst development and size, highlighting the importance of these conditions for risk assessment and surgical planning.

This case report describes a 10-year-old patient with a rare trichilemmal cyst in the cervical region, highlighting the importance of close monitoring due to potential risks of malignancy.