TLDR Topical tretinoin effectively treated sebaceous filaments, improving skin appearance.
This case report describes a 16-year-old African American girl with a two-year history of white spicules on her face, diagnosed as sebaceous filaments. Histopathology confirmed the presence of cornified cells and calcification. Sebaceous filaments, caused by sebum accumulation and keratinocytes around hair follicles, are rare and likely under-reported. Treatment focuses on reducing sebaceous gland size to improve skin appearance. The patient was successfully treated with topical tretinoin, highlighting the importance of recognizing and managing this condition to enhance patients' quality of life.
7 citations,
February 2021 in “Dermatologic Therapy” Sebaceous glands are involved in various skin disorders, some treatable with medications like finasteride and minoxidil.
13 citations,
December 2020 in “Dermatologic Therapy” Sebaceous glands in our skin, developing during pregnancy and active in puberty, produce sebum for skin lubrication, temperature control, and fighting germs, also help in hormone regulation, and their dysfunction can cause conditions like acne and hair loss.
13 citations,
June 2020 in “Scientific reports” Melatonin stimulates the skin components of ram's scrotum during their non-breeding season.
9 citations,
January 2017 in “Elsevier eBooks” Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
83 citations,
May 2013 in “International Journal of Molecular Sciences” Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.
4 citations,
June 2023 in “Journal of developmental biology” The skin systems of jawed vertebrates evolved diverse appendages like hair and scales from a common structure over 420 million years ago.
