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A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.

The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

The research helps understand how finasteride works and aids drug development.

Bee venom helps hair grow and may work better than some common treatments.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

*Laportea bulbifera* contains unique compounds that may help treat benign prostatic hyperplasia.

The plant extract and minoxidil both reduce hair loss by lowering specific gene expressions.

Longer TA repeats in the SRD5A2 gene may increase acne risk in Chinese people.

Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose can help treat hair loss by reducing certain hormones and promoting hair growth.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Rice bran extract might help prevent hair loss.

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.

Testosterone helps human pancreatic cells increase insulin release.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Androgens can both increase body hair and cause scalp hair loss.

The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.

Higher sebum levels are linked to more severe male baldness.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Costunolide helps human hair cells grow and can stimulate hair growth in mice.

Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.

Protein tyrosine kinases are key in male pattern baldness, affecting skin structure, hair growth, and immune responses.

Post-finasteride syndrome's existence is uncertain; more research needed.

DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.