Phytochemical, Chemotaxonomic and Bioinformatics Study on Laportea Bulbifera (Urticaceae)

    May 2022 in “ Chemistry & biodiversity ”
    Xuan Lu, Yuxuan Zhao, Bo Li, Weixing Feng, Junkai Qi, Baomin Feng
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    TLDR *Laportea bulbifera* contains unique compounds that may help treat benign prostatic hyperplasia.
    The study on *Laportea bulbifera* identified 17 compounds, including flavonoids, terpenoids, phenolic acids, coumarins, steroids, and alkaloids. Notably, some compounds were isolated for the first time from the Urticaceae family and the genus *Laportea*. The research highlighted the chemotaxonomic significance of certain compounds, suggesting that isoflavones could distinguish between species of *L. bulbifera* and the genus *Urtica*. Molecular docking showed that several compounds had a better inhibitory effect on human steroid 5α-reductase 2 (SRD5α2) than finasteride, indicating potential for treating benign prostatic hyperplasia (BPH). This study supports future phytochemical and chemotaxonomic research on *Laportea* and its therapeutic applications.
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