Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses how mesenchymal stromal cell-based therapy holds promise for treating age-related diseases, given its potential to target aging's pathological features, although significant challenges remain for its clinical application.

This review discusses the repurposing of natural products for COVID-19 treatment but reports no new clinical findings, highlighting ongoing research to target host and viral mechanisms.

This study reports that high expression of proteins ST14 and TMEFF1 in ovarian cancer correlates with higher tumor malignancy and worse prognosis, and reveals an interaction where ST14 regulates TMEFF1 to promote cancer cell proliferation, migration, and invasion.

In this study, researchers used a new method with platelet-rich plasma-loaded microcarriers to enhance dermal papilla cell activity and hair follicle regeneration, achieving significant hair and vessel growth in a mouse model compared to control groups.

This review outlines strategies for regulating macrophage response using bioactive materials to enhance wound healing, focusing on extracellular matrix-based scaffolds and nanofibrous composites, but reports no new clinical results.

This review discusses how immune mechanisms contribute to the regeneration and repair of epithelial tissues and highlights their potential role in both disease and therapeutic innovation; it reports no new clinical results.

This review discusses the role of extracellular vesicles in bone regeneration and their potential as therapeutics, highlighting challenges like standardization and safety for clinical application, but it reports no new clinical results.

This study found that compound 3 derived from aza-bicyclo-carboxylic acid may exert a cardioprotective effect by reducing infarction area in myocardial ischemia-reperfusion injury, potentially involving A1-adenosine receptor activation and changes in cAMP levels.

This review discusses how chronic inflammation can lead to persistent stem cell activation and DNA damage, ultimately promoting cancer development and metastasis, but reports no new results.

This review discusses key molecular targets in cosmetic research and reports no clinical results; it highlights the role of telomerase, sirtuins, and tyrosinase in anti-aging and depigmentation strategies.

Certain genetic variants and pathways are linked to hair loss.

This review discusses the role and regulation of quiescent adult stem cells in tissue maintenance and repair, focusing on molecular mechanisms and their implications for regenerative medicine, but reports no new clinical results.

Targeting THY1 can improve skin repair and healing.

This comprehensive review suggests that CD44 signaling plays a significant role in post-natal skin wound healing and scar formation, with potential for therapeutic approaches targeting CD44 to shift from fibrotic scarring towards regenerative healing, including wound regeneration and hair neogenesis.

This study found that Plerixafor, a CXCR4 antagonist, promotes melanogenesis in melanocytes by increasing MITF and tyrosinase expression and enhancing melanocyte migration, and it effectively restores pigmentation in a mouse depigmentation model without toxicity, highlighting its potential for treating pigmentary disorders.

This review discusses the role of vitamin D receptor signaling in hair follicle biology for alopecia treatment and underscores the need for continued research, without presenting new clinical results.

This study highlights IGF-1's role in promoting hair follicle proliferation, vascularization, and growth, suggesting its potential as a treatment target for hair loss disorders like androgenetic alopecia, though more research on delivery methods and long-term effects is needed.

This review discusses the potential of ginseng and its metabolites for treating hair loss and reports no new clinical findings.

This study found that Hirosaki hairless rats experience transient activation of STAT5A in the mammary glands during early lactation, involving O-GlcNAc modification rather than Tyr-phosphorylation.

This study observed that overexpression of TGF-alpha in transgenic mice led to thicker epidermis and stunted hair growth, particularly in regions with normally thick skin and low hair density.

This review discusses the roles estrogens play in males and androgens in females, challenging the traditional view of strictly "male" and "female" hormones, but it does not report new experimental findings.

This review summarizes recent findings on keratins 6, 16, and 17, highlighting their role in keratinocyte behavior and nuclear functions, and discusses their potential as biomarkers for various skin pathologies, including damage, inflammation, and cancer, rather than in healthy skin.

This review discusses the role of YAP/TAZ proteins in skin cancer physiology and tumorigenesis, and the potential of targeting these proteins in skin cancer treatments, but presents no new experimental findings.