Inflammatory Auxo-Action in the Stem Cell Division Theory of Cancer

This review discusses the role of inflammation in cancer development, particularly through the lens of the stem cell division theory. While acute inflammation is beneficial for tissue repair, chronic inflammation can lead to cancer by continuously exposing cells to pro-inflammatory cytokines and activating inflammatory pathways. This persistent inflammation drives stem cells to divide, increasing the risk of accumulating genetic mutations that can lead to cancer. The review highlights that chronic inflammation not only promotes the transformation of normal stem cells into cancerous ones but also aids in cancer metastasis. The study emphasizes the need for further research on how inflammation affects cancer formation from stem cells.