Inflammatory Auxo-Action in the Stem Cell Division Theory of Cancer

The document is a peer review of a manuscript discussing the relationship between inflammation and its impact on cancer stem cells and cancer progression. The reviewers were generally satisfied with the revised manuscript, noting that the authors addressed most of their comments. However, they recommended major revisions, including a clearer rationale, inclusion of recent developments about inflammatory regulators in the tumor microenvironment, and a separate section about different immune cells' role in regulating the tumor microenvironment. They also suggested including studies that indicate inflammation reduces cancer growth and future studies to stimulate further research. The reviewers identified areas needing more information or clarity, such as the influence of inflammation on nonmalignant stem cell behavior, the difference between normal and dormant stem cells, and the pathways contributing to nonmalignant stem cells' survival, proliferation, self-renewal, and differentiation. They also suggested strengthening the conclusion.