Inflammatory Auxo-Action in the Stem Cell Division Theory of Cancer
June 2023
TLDR The reviewers suggest clarifying and expanding on the role of inflammation in stem cell-related cancer development.
The document is a peer review of a study investigating the role of inflammatory responses in the stem cell division theory of cancer. The initial manuscript had issues with clarity, repetition, and undefined abbreviations, but these were addressed in the revised version. The reviewers found the topic extensive and relevant. They suggested improvements such as revising the abstract, expanding on how DNA errors affect inflammatory responses in stem cells, providing more background information on the effect of inflammatory responses on stem cells and cancer progression, discussing the role of different immune cells in the tumor microenvironment, and including studies that suggest inflammation lowers cancer growth. They also recommended rewriting the conclusion, defining abbreviations, and updating the reference section.