Inflammatory Responses in the Stem Cell Division Theory of Cancer
June 2023
Studysummary This review highlights that chronic inflammation leads to ongoing activation of stem cells, causing DNA damage accumulation, which can promote cancer development and metastasis.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The document is a peer review of a study titled "The role of inflammatory responses in stem cell division theory of cancer". The initial manuscript had issues with clarity, repetition, and undefined abbreviations, but these were addressed in the revised version. The study explores the impact of inflammatory responses on cancer stem cell transition and progression. Reviewers found the topic extensive, relevant, and the manuscript well-structured. They appreciated the comprehensive literature review conducted by the authors. The reviewers suggested improvements such as revising the abstract for clarity, providing more background information on the effect of inflammatory responses on stem cells and cancer progression, discussing the role of different immune cells in regulating the tumor microenvironment, and including future studies and open questions to stimulate further research. Despite some initial issues, the manuscript was accepted in its revised format.
