Search
for

    Did you mean Squamous Cell Carcinoma?
    Glossary Squamous Cell Carcinoma

    type of skin cancer originating in outer epidermal cells

    Squamous Cell Carcinoma (SCC) is a type of skin cancer that originates in the squamous cells, which are flat cells located in the outer part of the epidermis. It often appears as a red, scaly patch, open sore, or wart-like growth that may crust or bleed. While it can be aggressive and spread to other parts of the body if not treated, it is generally curable when detected early.

    Related Terms

    Sort by

    Research 30 of 1000+

    1. Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin Nature communications · 2019 · 36 citations
    2. Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis American Journal Of Pathology · 2006 · 100 citations
    3. Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶ Photochemistry and Photobiology · 2005 · 28 citations
    4. Bilateral Squamous Cell Carcinoma of the Forehead 2020
    5. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas Publisher · 2019
    6. The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells Pharmaceuticals · 2021 · 48 citations
    7. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas Genes & Diseases · 2019 · 31 citations
    8. Aggressive Squamous Carcinomas of the Scalp Dermatologic Surgery · 2006 · 18 citations
    9. No Evidence That Human Papillomavirus Is Responsible for the Aggressive Nature of Recessive Dystrophic Epidermolysis Bullosa–Associated Squamous Cell Carcinoma Journal of Investigative Dermatology · 2010 · 14 citations
    10. RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development Orphanet journal of rare diseases · 2022 · 5 citations
    11. Synthetic Hair Implantation and Squamous Cell Carcinoma of the Scalp Aesthetic Plastic Surgery · 2012 · 2 citations
    12. GSDMA deficiency impairs cutaneous squamous cell carcinoma growth Frontiers in Oncology · 2026
    13. Case report: Novel p.Val306Met missense mutation in TRPV3 in a case of Olmsted syndrome accompanied by squamous cell carcinoma Frontiers in Oncology · 2024
    14. Resolution of advanced conjunctival squamous cell carcinoma with cemiplimab immunotherapy, IFNα-2b, and retinoic acid treatment over 2 years of follow-up Canadian Journal of Ophthalmology · 2024
    15. Aggressive Squamous Carcinomas of the Scalp Dermatologic Surgery · 2006
    16. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell stem cell · 2016 · 174 citations
    17. YAP and TAZ are essential for basal and squamous cell carcinoma initiation EMBO Reports · 2018 · 76 citations
    18. Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3 Cancer Research · 2007 · 76 citations
    19. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 65 citations
    20. Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of <i>Retinoblastoma</i> and <i>Trp53</i> Tumor Suppressors Cancer Research · 2008 · 64 citations
    21. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 64 citations
    22. Keratoacanthoma and other types of squamous cell carcinoma with crateriform architecture: Classification and identification The Journal of Dermatology · 2013 · 45 citations
    23. Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2 Cancer Research · 2006 · 35 citations
    24. Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Cancer research · 2018 · 34 citations
    25. Aggressive squamous cell carcinoma developing in a giant epidermal cyst of the abdomen International Journal of Dermatology · 2006 · 16 citations
    26. Squamous cell carcinoma arising within folliculitis decalvans British Journal of Dermatology · 2008 · 15 citations
    27. Twist1 is required for the development of UVB‐induced squamous cell carcinoma Molecular Carcinogenesis · 2021 · 11 citations
    28. Connexin 26 (<i>GJB2</i>) mutations in keratitis–ichthyosis–deafness syndrome presenting with squamous cell carcinoma The Journal of Dermatology · 2011 · 11 citations
    29. Protein Kinase C<i>ε</i>, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells Journal of skin cancer · 2013 · 10 citations
    30. Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma Experimental Dermatology · 2016 · 8 citations