Profile Analysis of Adverse Events After Boron Neutron Capture Therapy for Head and Neck Cancer: A Sub-Analysis of the JHN002 Study

    March 2022 in “ Journal of radiation research ”
    Katsumi Hirose, Mariko Sato, Takahiro Katō, Kanako Takayama, Motohisa Suzuki, H. Yamaguchi, Ichiro Seto, Yasuhiro Kikuchi, Masao Murakami, Yoshihiro Takai
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    TLDR Boron neutron capture therapy for head and neck cancer can cause side effects like mouth sores and skin irritation, which vary depending on where the treatment is aimed.
    This study conducted a sub-analysis of the phase II JHN002 trial to examine the adverse events associated with boron neutron capture therapy (BNCT) for head and neck cancer. A total of 21 patients with recurrent squamous cell carcinoma (R-SCC) and non-SCC were analyzed, with adverse events tracked based on the incidence position of the neutron beam on the skin. The median recovery times for various adverse events were reported: 23 days for oral mucositis, 40 days for dermatitis, 58 days for dysgeusia, and 156 days for alopecia. The study found that the face/front (FF) beam group experienced less frequent parotitis but more frequent oral mucositis, fatigue, conjunctivitis, epistaxis, and abdominal discomfort compared to the face/lateral (FL) and neck (N) beam groups. These findings highlight the importance of considering the irradiation site when planning BNCT to potentially prevent or mitigate treatment-related adverse events.
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