Efficacy of Albumin-Bound Paclitaxel Combined with Nedaplatin in Neoadjuvant Therapy for Esophageal Squamous Cell Carcinoma: A Single-Center Retrospective Observational Study

    March 2023 in “ Medicine
    Jiakuan Chen, Jianfei Zhu, Yan Zhang, Wen‐Chen Wang, Yanmin Xia, Jinbo Zhao, Tao Jiang
    TLDR The combination therapy is effective and well-tolerated for treating esophageal cancer.
    This single-center retrospective observational study assessed the efficacy and safety of albumin-bound paclitaxel combined with nedaplatin as neoadjuvant therapy for esophageal squamous cell carcinoma (ESCC) in 41 patients. The study achieved a 100% R0 resection rate, with a 17.1% pathological complete response (pCR) rate and 51.2% of patients experiencing tumor downstaging. Common adverse events included hematologic toxicity (24.4%) and gastrointestinal reactions (17.1%), with no grade 4 or higher events. The results indicate that this combination therapy is effective and well-tolerated, offering a potential alternative to more toxic regimens, though the study's small sample size and lack of a control group are limitations.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community My Testosterone results before and after Finasteride

      in Update  149 upvotes 3 years ago
      Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

      community 31M - major hair shedding after weight loss + stopping vitamins — help!

      in Minoxidil  4 upvotes 1 month ago
      A 31-year-old male experienced hair shedding after rapid weight loss and stopping vitamins, despite using minoxidil and other supplements. He is considering Saw Palmetto and Pumpkin Seed Oil instead of finasteride due to trying for kids, and is concerned about high ferritin and DHEAS levels.

      community Help interpreting pre-fin bloodwork

      in Finasteride/Dutasteride  12 upvotes 4 years ago
      A 20-year-old male is unsure how to interpret his bloodwork results and whether he should take finasteride for hair loss. His bloodwork shows borderline high levels of albumin and testosterone, and high progesterone, but normal levels of other hormones.

      community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

      in Female  42 upvotes 4 years ago
      User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.

      community Dutasteride and elevated (LDL) cholesterol

      in Finasteride/Dutasteride  1 upvotes 2 months ago
      The user switched from finasteride to dutasteride for hair loss and noticed elevated cholesterol levels, questioning if dutasteride caused this change. They also take Vitamin D, biotin, magnesium, ginkgo biloba, omega-3, and NAC, and are concerned about the impact of these supplements and their health on cholesterol levels.

    Similar Research

    5 / 1000+ results