MmuPV1 Infection and Tumor Development in T Cell-Deficient Mice Prevented by Passively Transferred Hyperimmune Sera from Normal Congenic Mice Immunized with MmuPV1 Virus-Like Particles

January 2016 in “ Experimental and molecular pathology ”

Joongho Joh, Shin-je Ghim, Paula M. Chilton, John P. Sundberg, Jino Park, Sarah A. Wilcher, Mary Proctor, A. Bennett Jenson

T cell-deficient squamous papillomas hair follicle tumors mouse papillomavirus MmuPV1 hyperimmune sera virus-like particles VLPs

TLDR Giving immune serum from vaccinated mice to mice without T cells prevents infection and tumor growth.

The study demonstrated that T cell-deficient B6.Cg-Foxn1nu/J nude mice developed four types of squamous papillomas and hair follicle tumors after being infected with mouse papillomavirus (MmuPV1). These tumors appeared on various parts of the body between 26 and 42 days post-inoculation. However, when these mice were given hyperimmune sera from normal mice that had been immunized with MmuPV1 virus-like particles (VLPs), they were protected from infection and subsequent tumor development. This finding underscores the importance of T cells in preventing tumor formation following MmuPV1 infection.

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