Cronkhite-Canada Syndrome Associated With Superficial Esophageal Carcinoma: A Case Report and Literature Review

    March 2022 in “ Frontiers in Medicine
    Yan Zhao, Fujing Lv, Yang Xun, Yongjun Wang, Shutian Zhang, Peng Li
    Studysummary This case report highlights a rare instance of esophageal carcinoma in a patient with Cronkhite-Canada syndrome, emphasizing the importance of endoscopic surveillance for malignant gastrointestinal tumors in these patients. Our plain-language summary of this paper — not a Tressless recommendation.
    This case report discusses a 67-year-old man with Cronkhite-Canada syndrome (CCS) who developed early esophageal carcinoma, a rare comorbidity. The patient was treated with endoscopic submucosal dissection for the esophageal lesion and endoscopic mucosal resection for colon polyps, followed by glucocorticoid therapy. The treatment was successful, with no recurrence of esophageal carcinoma and a decrease in gastrointestinal polyps over an 18-month follow-up. The case highlights the importance of regular endoscopic surveillance in CCS patients due to the potential for malignant transformation.
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