Alopecia Areata Incognita in Cronkhite-Canada Syndrome

    December 2016 in “ British Journal of Dermatology ”
    Shin Yeu Ong, Cristina Rodríguez-García, Sophie Grabczynska, James Carton, Michael Osborn, Julian R.F. Walters, Faris Kubba, Catherine M. Stefanato
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    TLDR The report suggests that hair loss in Cronkhite-Canada syndrome may be caused by alopecia areata incognita, as shown by a patient's improvement with treatment.
    The case report described a 49-year-old Chinese woman with Cronkhite-Canada syndrome who experienced rapid and extensive hair loss, gastrointestinal symptoms, and nail changes. A scalp biopsy indicated a possible mechanism of hair loss as alopecia areata incognita, characterized by a 'shift out of anagen' and increased telogen hair follicles with peri-bulbar lymphoid cell infiltrate. Treatment with prednisolone and mesalazine resulted in symptom improvement and hair and nail regrowth. This study suggested alopecia areata incognita as a potential cause of hair loss in Cronkhite-Canada syndrome, evidenced by the patient's response to treatment and biopsy results.
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