A Case Report of Cronkhite-Canada Syndrome Complicated by Membranous Nephropathy

November 2018 in “ Case reports in nephrology and dialysis ”

Christine Firth, Lucinda A. Harris, Maxwell L. Smith, Leslie Thomas

Cronkhite-Canada Syndrome alopecia skin hyperpigmentation onychodystrophy nephrotic syndrome prednisone azathioprine cyclosporine rituximab corticosteroid therapy immunosuppressive treatment hair loss skin discoloration nail dystrophy steroid therapy

TLDR Rituximab may be an effective treatment for Cronkhite-Canada syndrome with kidney disease.

The document reported a case of a 70-year-old man with Cronkhite-Canada Syndrome (CCS) complicated by membranous nephropathy (MN). CCS is a rare disease characterized by gastrointestinal polyposis, alopecia, skin hyperpigmentation, and onychodystrophy. The patient presented with symptoms like diarrhea, weight loss, and hair loss, and later developed nephrotic syndrome. Initial treatments with prednisone, azathioprine, and cyclosporine led to moderate improvement in CCS symptoms but not in proteinuria. The addition of rituximab resulted in remission of MN and significant improvement in polyposis and cutaneous symptoms. The case highlighted the importance of considering renal complications in CCS and suggested rituximab as a potential treatment for refractory CCS and associated MN. The patient's condition improved with corticosteroid therapy, emphasizing the role of immunosuppressive treatment.

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